Spliceosomal immunophilins.

Journal Article (Journal Article;Review)

The spliceosome is a dynamic, macromolecular complex, which removes non-protein-coding introns from pre-mRNA to form mature mRNA in a process known as splicing. This ribonucleoprotein assembly is comprised of five uridine-rich small nuclear RNAs (snRNAs) as well as over 300 proteins. In humans, several of the known proteinaceous splicing factors are members of the immunophilin superfamily. Immunophilins are peptidyl-prolyl cis-trans isomerases that catalyze the conversion of proteins from cis to trans at Xaa-Pro bonds. Our review of the data indicates that some members of this protein family are activators of spliceosomal proteins by way of folding and transport.

Full Text

Duke Authors

Cited Authors

  • Mesa, A; Somarelli, JA; Herrera, RJ

Published Date

  • July 9, 2008

Published In

Volume / Issue

  • 582 / 16

Start / End Page

  • 2345 - 2351

PubMed ID

  • 18544344

Pubmed Central ID

  • PMC2546689

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2008.06.006


  • eng

Conference Location

  • England