Colorectal cancer surveillance in inflammatory bowel disease: Practice guidelines and recent developments.

Journal Article (Journal Article;Review)

Patients with long-standing inflammatory bowel disease (IBD) involving at least 1/3 of the colon are at increased risk for colorectal cancer (CRC). Advancements in CRC screening and surveillance and improved treatment of IBD has reduced CRC incidence in patients with ulcerative colitis and Crohn's colitis. Most cases of CRC are thought to arise from dysplasia, and recent evidence suggests that the majority of dysplastic lesions in patients with IBD are visible, in part thanks to advancements in high definition colonoscopy and chromoendoscopy. Recent practice guidelines have supported the use of chromoendoscopy with targeted biopsies of visible lesions rather than traditional random biopsies. Endoscopists are encouraged to endoscopically resect visible dysplasia and only recommend surgery when a complete resection is not possible. New technologies such as virtual chromoendoscopy are emerging as potential tools in CRC screening. Patients with IBD at increased risk for developing CRC should undergo surveillance colonoscopy using new approaches and techniques.

Full Text

Duke Authors

Cited Authors

  • Clarke, WT; Feuerstein, JD

Published Date

  • August 14, 2019

Published In

Volume / Issue

  • 25 / 30

Start / End Page

  • 4148 - 4157

PubMed ID

  • 31435169

Pubmed Central ID

  • PMC6700690

Electronic International Standard Serial Number (EISSN)

  • 2219-2840

Digital Object Identifier (DOI)

  • 10.3748/wjg.v25.i30.4148


  • eng

Conference Location

  • United States