Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity.

Journal Article (Journal Article)

Capabilities in real-time monitoring of internal physiological processes could inform pharmacological drug-delivery schedules, surgical intervention procedures and the management of recovery and rehabilitation. Current methods rely on external imaging techniques or implantable sensors, without the ability to provide continuous information over clinically relevant timescales, and/or with requirements in surgical procedures with associated costs and risks. Here, we describe injectable classes of photonic devices, made entirely of materials that naturally resorb and undergo clearance from the body after a controlled operational lifetime, for the spectroscopic characterization of targeted tissues and biofluids. As an example application, we show that the devices can be used for the continuous monitoring of cerebral temperature, oxygenation and neural activity in freely moving mice. These types of devices should prove useful in fundamental studies of disease pathology, in neuroscience research, in surgical procedures and in monitoring of recovery from injury or illness.

Full Text

Duke Authors

Cited Authors

  • Bai, W; Shin, J; Fu, R; Kandela, I; Lu, D; Ni, X; Park, Y; Liu, Z; Hang, T; Wu, D; Liu, Y; Haney, CR; Stepien, I; Yang, Q; Zhao, J; Nandoliya, KR; Zhang, H; Sheng, X; Yin, L; MacRenaris, K; Brikha, A; Aird, F; Pezhouh, M; Hornick, J; Zhou, W; Rogers, JA

Published Date

  • August 2019

Published In

Volume / Issue

  • 3 / 8

Start / End Page

  • 644 - 654

PubMed ID

  • 31391594

Electronic International Standard Serial Number (EISSN)

  • 2157-846X

International Standard Serial Number (ISSN)

  • 2157-846X

Digital Object Identifier (DOI)

  • 10.1038/s41551-019-0435-y


  • eng