The Sphenopalatine Ganglion: Anatomy, Pathophysiology, and Therapeutic Targeting in Headache.

Journal Article (Journal Article;Review)

The sphenopalatine ganglion (SPG) has attracted the interest of practitioners treating head and face pain for over a century because of its anatomical connections and role in the trigemino-autonomic reflex. In this review, we discuss the anatomy of the SPG, as well as what is known about its role in the pathophysiology of headache disorders, including cluster headache and migraine. We then address various therapies that target the SPG, including intranasal medication delivery, new SPG blocking catheter devices, neurostimulation, chemical neurolysis, and ablation procedures.

Full Text

Duke Authors

Cited Authors

  • Robbins, MS; Robertson, CE; Kaplan, E; Ailani, J; Charleston, L; Kuruvilla, D; Blumenfeld, A; Berliner, R; Rosen, NL; Duarte, R; Vidwan, J; Halker, RB; Gill, N; Ashkenazi, A

Published Date

  • February 2016

Published In

Volume / Issue

  • 56 / 2

Start / End Page

  • 240 - 258

PubMed ID

  • 26615983

Electronic International Standard Serial Number (EISSN)

  • 1526-4610

Digital Object Identifier (DOI)

  • 10.1111/head.12729


  • eng

Conference Location

  • United States