Sexual fidelity trade-offs promote regulatory variation in the prairie vole brain.

Journal Article (Journal Article)

Individual variation in social behavior seems ubiquitous, but we know little about how it relates to brain diversity. Among monogamous prairie voles, levels of vasopressin receptor (encoded by the gene avpr1a) in brain regions related to spatial memory predict male space use and sexual fidelity in the field. We find that trade-offs between the benefits of male fidelity and infidelity are reflected in patterns of territorial intrusion, offspring paternity, avpr1a expression, and the evolutionary fitness of alternative avpr1a alleles. DNA variation at the avpr1a locus includes polymorphisms that reliably predict the epigenetic status and neural expression of avpr1a, and patterns of DNA diversity demonstrate that avpr1a regulatory variation has been favored by selection. In prairie voles, trade-offs in the fitness consequences of social behaviors seem to promote neuronal and molecular diversity.

Full Text

Duke Authors

Cited Authors

  • Okhovat, M; Berrio, A; Wallace, G; Ophir, AG; Phelps, SM

Published Date

  • December 2015

Published In

Volume / Issue

  • 350 / 6266

Start / End Page

  • 1371 - 1374

PubMed ID

  • 26659055

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.aac5791


  • eng