An inhibitor of K+ channels modulates human endometrial tumor-initiating cells.

Journal Article (Journal Article)

BACKGROUND: Many potassium ion (K+) channels function as oncogenes to sustain growth of solid tumors, but their role in cancer progression is not well understood. Emerging evidence suggests that the early progenitor cancer cell subpopulation, termed tumor initiating cells (TIC), are critical to cancer progression. RESULTS: A non-selective antagonist of multiple types of K+ channels, tetraethylammonium (TEA), was found to suppress colony formation in endometrial cancer cells via inhibition of putative TIC. The data also indicated that withdrawal of TEA results in a significant enhancement of tumorigenesis. When the TIC-enriched subpopulation was isolated from the endometrial cancer cells, TEA was also found to inhibit growth in vitro. CONCLUSIONS: These studies suggest that the activity of potassium channels significantly contributes to the progression of endometrial tumors, and the antagonists of potassium channels are candidate anti-cancer drugs to specifically target tumor initiating cells in endometrial cancer therapy.

Full Text

Duke Authors

Cited Authors

  • Schickling, BM; Aykin-Burns, N; Leslie, KK; Spitz, DR; Korovkina, VP

Published Date

  • August 2, 2011

Published In

Volume / Issue

  • 11 / 1

Start / End Page

  • 25 -

PubMed ID

  • 21810252

Pubmed Central ID

  • PMC3175438

Electronic International Standard Serial Number (EISSN)

  • 1475-2867

Digital Object Identifier (DOI)

  • 10.1186/1475-2867-11-25

Language

  • eng

Conference Location

  • England