Novel therapies are changing treatment paradigms in metastatic prostate cancer.

Journal Article (Journal Article;Review)

Metastatic castration-resistant prostate cancer (mCRPC) remains a terminal diagnosis with an aggressive disease course despite currently approved therapeutics. The recent successful development of poly ADP-ribose polymerase (PARP) inhibitors for patients with mCRPC and mutations in DNA damage repair genes has added to the treatment armamentarium and improved personalized treatments for prostate cancer. Other promising therapeutic agents currently in clinical development include the radiotherapeutic 177-lutetium-prostate-specific membrane antigen (PSMA)-617 targeting PSMA-expressing prostate cancer and combinations of immunotherapy with currently effective treatment options for prostate cancer. Herein, we have highlighted the progress in systemic treatments for mCRPC and the promising agents currently in ongoing clinical trials.

Full Text

Duke Authors

Cited Authors

  • Powers, E; Karachaliou, GS; Kao, C; Harrison, MR; Hoimes, CJ; George, DJ; Armstrong, AJ; Zhang, T

Published Date

  • October 28, 2020

Published In

Volume / Issue

  • 13 / 1

Start / End Page

  • 144 -

PubMed ID

  • 33115529

Pubmed Central ID

  • PMC7594418

Electronic International Standard Serial Number (EISSN)

  • 1756-8722

Digital Object Identifier (DOI)

  • 10.1186/s13045-020-00978-z


  • eng

Conference Location

  • England