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Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.

Publication ,  Journal Article
Guo, H; Chou, W-C; Lai, Y; Liang, K; Tam, JW; Brickey, WJ; Chen, L; Montgomery, ND; Li, X; Bohannon, LM; Sung, AD; Chao, NJ; Peled, JU ...
Published in: Science
October 30, 2020

Ionizing radiation causes acute radiation syndrome, which leads to hematopoietic, gastrointestinal, and cerebrovascular injuries. We investigated a population of mice that recovered from high-dose radiation to live normal life spans. These "elite-survivors" harbored distinct gut microbiota that developed after radiation and protected against radiation-induced damage and death in both germ-free and conventionally housed recipients. Elevated abundances of members of the bacterial taxa Lachnospiraceae and Enterococcaceae were associated with postradiation restoration of hematopoiesis and gastrointestinal repair. These bacteria were also found to be more abundant in leukemia patients undergoing radiotherapy, who also displayed milder gastrointestinal dysfunction. In our study in mice, metabolomics revealed increased fecal concentrations of microbially derived propionate and tryptophan metabolites in elite-survivors. The administration of these metabolites caused long-term radioprotection, mitigation of hematopoietic and gastrointestinal syndromes, and a reduction in proinflammatory responses.

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

October 30, 2020

Volume

370

Issue

6516

Location

United States

Related Subject Headings

  • Tryptophan
  • Survivors
  • Radiation Protection
  • Mice, Inbred C57BL
  • Mice
  • Metabolomics
  • Humans
  • General Science & Technology
  • Gastrointestinal Microbiome
  • Fatty Acids, Volatile
 

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Chicago
ICMJE
MLA
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Guo, H., Chou, W.-C., Lai, Y., Liang, K., Tam, J. W., Brickey, W. J., … Ting, J. P. Y. (2020). Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science, 370(6516). https://doi.org/10.1126/science.aay9097
Guo, Hao, Wei-Chun Chou, Yunjia Lai, Kaixin Liang, Jason W. Tam, W June Brickey, Liang Chen, et al. “Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.Science 370, no. 6516 (October 30, 2020). https://doi.org/10.1126/science.aay9097.
Guo H, Chou W-C, Lai Y, Liang K, Tam JW, Brickey WJ, et al. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 2020 Oct 30;370(6516).
Guo, Hao, et al. “Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites.Science, vol. 370, no. 6516, Oct. 2020. Pubmed, doi:10.1126/science.aay9097.
Guo H, Chou W-C, Lai Y, Liang K, Tam JW, Brickey WJ, Chen L, Montgomery ND, Li X, Bohannon LM, Sung AD, Chao NJ, Peled JU, Gomes ALC, van den Brink MRM, French MJ, Macintyre AN, Sempowski GD, Tan X, Sartor RB, Lu K, Ting JPY. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 2020 Oct 30;370(6516).
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

October 30, 2020

Volume

370

Issue

6516

Location

United States

Related Subject Headings

  • Tryptophan
  • Survivors
  • Radiation Protection
  • Mice, Inbred C57BL
  • Mice
  • Metabolomics
  • Humans
  • General Science & Technology
  • Gastrointestinal Microbiome
  • Fatty Acids, Volatile