Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla.

Journal Article (Journal Article)

During a chemical investigation of Wikstroemia scytophylla, three new [wikstrocins A-C (1-3)] and three known tigliane diterpenoids (4-6) were isolated. The structures of the new compounds were elucidated from extensive physiochemical and spectroscopic analysis. The correlations between the ECD Cotton effects and B ring structures of tiglianes were also evaluated. The isolated compounds were assessed for their anti-HIV activity against HIV-1 infection of MT4 cells, and two compounds (4 and 6) showed potent anti-HIV activity with IC50 values of 3.8 and 12.8 nM, respectively.

Full Text

Duke Authors

Cited Authors

  • Otsuki, K; Zhang, M; Yamamoto, A; Tsuji, M; Tejima, M; Bai, Z-S; Zhou, D; Huang, L; Chen, C-H; Lee, K-H; Li, N; Li, W; Koike, K

Published Date

  • December 24, 2020

Published In

Volume / Issue

  • 83 / 12

Start / End Page

  • 3584 - 3590

PubMed ID

  • 33172265

Pubmed Central ID

  • PMC8176626

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

Digital Object Identifier (DOI)

  • 10.1021/acs.jnatprod.0c00700

Language

  • eng

Conference Location

  • United States