Heterogeneity of health status treatment response with sacubitril/valsartan: insights from the CHAMP-HF registry.

Journal Article (Journal Article)

AIMS: The aim of our study was to investigate heterogeneity of health status treatment response of sacubitril/valsartan in patients with heart failure with reduced ejection fraction (HFrEF). METHODS AND RESULTS: We leveraged data from CHAMP-HF, an observational registry of 140 US clinics and 5026 outpatients with chronic HFrEF, where health status was serially assessed using the Kansas City Cardiomyopathy Questionnaire (KCCQ)-12 Overall Summary Scale (range from 0 to 100; ≥20-point improvement is a very large improvement). In 334 patients newly initiated on sacubitril/valsartan, we used hierarchical multivariable logistic regression (13 patient-level characteristics as well as baseline KCCQ-12 score) to calculate the odds ratio (OR) of any characteristic being associated with a very large health status improvement. A total of 104/334 (31.1%) of patients achieved the primary endpoint, where only worse baseline health status [KCCQ-12 score of 0-60 points had an OR = 0.86/5-point higher score (CI 0.79, 0.93)], and those with a KCCQ-12 score of 60-80 points had an OR = 0.61/5-point higher score (0.45-0.82), which was associated with a very large benefit. No other patient characteristic was associated with a very large health status improvement (P > 0.05). CONCLUSIONS: We found that, after initiation of sacubitril/valsartan, only worse baseline health status was associated with very large health status improvement. Accordingly, a trial of therapy-particularly in those with worse symptoms, function, and quality of life-and assessing treatment response are likely to be the best prospective strategy.

Full Text

Duke Authors

Cited Authors

  • Khariton, Y; Fonarow, GC; Hellkamp, A; Thomas, L; Nassif, ME; Butler, J; Duffy, CI; Albert, NM; Spertus, JA

Published Date

  • February 2021

Published In

Volume / Issue

  • 8 / 1

Start / End Page

  • 710 - 713

PubMed ID

  • 33170559

Pubmed Central ID

  • PMC7835503

Electronic International Standard Serial Number (EISSN)

  • 2055-5822

Digital Object Identifier (DOI)

  • 10.1002/ehf2.12981


  • eng

Conference Location

  • England