Type III protein secretion systems in plant and animal pathogenic bacteria.


Journal Article

Among many interesting and sophisticated mechanisms used by bacterial pathogens to subvert eukaryotic hosts is a class of specialized protein secretion systems (known as type III protein secretion systems) that deliver bacterial virulence proteins directly into the host cell. Recent studies have revealed four important features of these secretion systems. First, they are widespread among plant and animal bacterial pathogens, and mutations affecting type III protein secretion often eliminate bacterial virulence completely. Second, at least eight type III secretion components share sequence similarities with those of the flagellar assembly machinery and flagellum-like structures are associated with type III secretion, raising the possibility that these secretion systems are derived from the presumably more ancient flagellar assembly apparatus. Third, type III secretion is activated in vivo upon contact with host cells. Fourth, the type III secretion mechanism is Sec-independent and the effector proteins may possess mRNA-based targeting signals. This review highlights the similarities and differences among type III secretion systems of selected model plant and animal pathogenic bacteria.

Full Text

Duke Authors

Cited Authors

  • He, SY

Published Date

  • January 1998

Published In

Volume / Issue

  • 36 /

Start / End Page

  • 363 - 392

PubMed ID

  • 15012505

Pubmed Central ID

  • 15012505

Electronic International Standard Serial Number (EISSN)

  • 1545-2107

International Standard Serial Number (ISSN)

  • 0066-4286

Digital Object Identifier (DOI)

  • 10.1146/annurev.phyto.36.1.363


  • eng