Effects of Nurse-Delivered Cognitive Behavioral Intervention on Depression and Anxiety for Persons Living With HIV in China: A Clinical Controlled Trial.

Journal Article (Journal Article)


Depression and anxiety, which may influence antiretroviral therapy (ART) medication adherence, are prevalent among persons living with HIV (PLWH) in China. This parallel two-arm clinical controlled trial aimed to examine the effects of a nurse-delivered cognitive behavioral intervention (CBI) on depression, anxiety, and ART medication adherence in Chinese PLWH. Using in-person and online recruitment, 140 PLWH ages 18 years and older who were undergoing ART and had a Patient Health Questionnaire-4 score of ≥2 were assigned to the 10-week-long CBI group or the routine follow-up group according to their preference. Outcomes were measured at baseline, postintervention, and 6-month follow-up. Results showed significant intervention effects on depression maintained until the 6-month follow-up. Although anxiety and ART medication adherence did not show robust effects between conditions, amelioration trends for these outcomes were also found. Our study demonstrated that the nurse-delivered CBI could help Chinese PLWH ameliorate depression.

Full Text

Duke Authors

Cited Authors

  • Han, S; Hu, Y; Relf, MV; Mulawa, MI; Lu, H; Zhang, L; Zhu, Z; Luo, J; Pei, Y; Wu, B

Published Date

  • January 2021

Published In

Volume / Issue

  • 32 / 1

Start / End Page

  • 79 - 93

PubMed ID

  • 33177434

Electronic International Standard Serial Number (EISSN)

  • 1552-6917

International Standard Serial Number (ISSN)

  • 1055-3290

Digital Object Identifier (DOI)

  • 10.1097/jnc.0000000000000213


  • eng