Functional Interplay Between Posterior Parietal Cortex and Hippocampus During Detection of Memory Targets and Non-targets.

Journal Article (Journal Article)

Posterior parietal cortex is frequently activated during episodic memory retrieval but its role during retrieval and its interactions with the hippocampus are not yet clear. In this fMRI study, we investigated the neural bases of recognition memory when study repetitions and retrieval goals were manipulated. During encoding participants studied words either once or three times, and during retrieval they were rewarded more to detect either studied words or new words. We found that (1) dorsal parietal cortex (DPC) was more engaged during detection of items studied once compared to three times, whereas regions in the ventral parietal cortex (VPC) responded more to items studied multiple times; (2) DPC, within a network of brain regions functionally connected to the anterior hippocampus, responded more to items consistent with retrieval goals (associated with high reward); (3) VPC, within a network of brain regions functionally connected to the posterior hippocampus, responded more to items not aligned with retrieval goals (i.e., unexpected). These findings support the hypothesis that DPC and VPC regions contribute differentially to top-down vs. bottom-up attention to memory. Moreover, they reveal a dissociation in the functional profile of the anterior and posterior hippocampi.

Full Text

Duke Authors

Cited Authors

  • Ciaramelli, E; Burianová, H; Vallesi, A; Cabeza, R; Moscovitch, M

Published Date

  • January 2020

Published In

Volume / Issue

  • 14 /

Start / End Page

  • 563768 -

PubMed ID

  • 33224020

Pubmed Central ID

  • PMC7670044

Electronic International Standard Serial Number (EISSN)

  • 1662-453X

International Standard Serial Number (ISSN)

  • 1662-4548

Digital Object Identifier (DOI)

  • 10.3389/fnins.2020.563768

Language

  • eng