Four-Point Bending Testing for Mechanical Assessment of Mouse Bone Structural Properties.

Journal Article (Journal Article)

One of the primary functions of bone is to support the skeleton by withstanding load. In the diseased state, bone's ability to perform this function is altered. Quantification of the features of bone that support its functional behavior, and how they may change with disease, is accomplished through mechanical testing. As such, mechanical testing is a useful tool for scientists studying orthopedic-related diseases. Furthermore, a common animal model used to investigate disease and its treatment is the mouse. Therefore, in this chapter we (1) describe central concepts of mechanical testing, (2) describe factors that influence the mechanical behavior of bone, and (3) describe the application of a widely used mechanical testing technique, four-point bending, to the mouse bone for characterization of its structural properties.

Full Text

Duke Authors

Cited Authors

  • Cutcliffe, HC; DeFrate, LE

Published Date

  • 2021

Published In

Volume / Issue

  • 2230 /

Start / End Page

  • 199 - 215

PubMed ID

  • 33197016

Electronic International Standard Serial Number (EISSN)

  • 1940-6029

Digital Object Identifier (DOI)

  • 10.1007/978-1-0716-1028-2_12


  • eng

Conference Location

  • United States