A genomic catalog of Earth's microbiomes.

Journal Article (Journal Article)

The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has enabled insights into the ecology and evolution of environmental and host-associated microbiomes. Here we applied this approach to >10,000 metagenomes collected from diverse habitats covering all of Earth's continents and oceans, including metagenomes from human and animal hosts, engineered environments, and natural and agricultural soils, to capture extant microbial, metabolic and functional potential. This comprehensive catalog includes 52,515 metagenome-assembled genomes representing 12,556 novel candidate species-level operational taxonomic units spanning 135 phyla. The catalog expands the known phylogenetic diversity of bacteria and archaea by 44% and is broadly available for streamlined comparative analyses, interactive exploration, metabolic modeling and bulk download. We demonstrate the utility of this collection for understanding secondary-metabolite biosynthetic potential and for resolving thousands of new host linkages to uncultivated viruses. This resource underscores the value of genome-centric approaches for revealing genomic properties of uncultivated microorganisms that affect ecosystem processes.

Full Text

Duke Authors

Cited Authors

  • Nayfach, S; Roux, S; Seshadri, R; Udwary, D; Varghese, N; Schulz, F; Wu, D; Paez-Espino, D; Chen, I-M; Huntemann, M; Palaniappan, K; Ladau, J; Mukherjee, S; Reddy, TBK; Nielsen, T; Kirton, E; Faria, JP; Edirisinghe, JN; Henry, CS; Jungbluth, SP; Chivian, D; Dehal, P; Wood-Charlson, EM; Arkin, AP; Tringe, SG; Visel, A; IMG/M Data Consortium, ; Woyke, T; Mouncey, NJ; Ivanova, NN; Kyrpides, NC; Eloe-Fadrosh, EA

Published Date

  • April 2021

Published In

Volume / Issue

  • 39 / 4

Start / End Page

  • 499 - 509

PubMed ID

  • 33169036

Pubmed Central ID

  • PMC8041624

Electronic International Standard Serial Number (EISSN)

  • 1546-1696

International Standard Serial Number (ISSN)

  • 1087-0156

Digital Object Identifier (DOI)

  • 10.1038/s41587-020-0718-6

Language

  • eng