Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.

Journal Article (Journal Article)

Spaceflight is known to impose changes on human physiology with unknown molecular etiologies. To reveal these causes, we used a multi-omics, systems biology analytical approach using biomedical profiles from fifty-nine astronauts and data from NASA's GeneLab derived from hundreds of samples flown in space to determine transcriptomic, proteomic, metabolomic, and epigenetic responses to spaceflight. Overall pathway analyses on the multi-omics datasets showed significant enrichment for mitochondrial processes, as well as innate immunity, chronic inflammation, cell cycle, circadian rhythm, and olfactory functions. Importantly, NASA's Twin Study provided a platform to confirm several of our principal findings. Evidence of altered mitochondrial function and DNA damage was also found in the urine and blood metabolic data compiled from the astronaut cohort and NASA Twin Study data, indicating mitochondrial stress as a consistent phenotype of spaceflight.

Full Text

Duke Authors

Cited Authors

  • da Silveira, WA; Fazelinia, H; Rosenthal, SB; Laiakis, EC; Kim, MS; Meydan, C; Kidane, Y; Rathi, KS; Smith, SM; Stear, B; Ying, Y; Zhang, Y; Foox, J; Zanello, S; Crucian, B; Wang, D; Nugent, A; Costa, HA; Zwart, SR; Schrepfer, S; Elworth, RAL; Sapoval, N; Treangen, T; MacKay, M; Gokhale, NS; Horner, SM; Singh, LN; Wallace, DC; Willey, JS; Schisler, JC; Meller, R; McDonald, JT; Fisch, KM; Hardiman, G; Taylor, D; Mason, CE; Costes, SV; Beheshti, A

Published Date

  • November 25, 2020

Published In

Volume / Issue

  • 183 / 5

Start / End Page

  • 1185 - 1201.e20

PubMed ID

  • 33242417

Pubmed Central ID

  • PMC7870178

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2020.11.002

Language

  • eng

Conference Location

  • United States