Characterization of Isavuconazole serum concentrations after enteral feeding tube administration in a hospitalized cohort: A case series.

Journal Article

WHAT IS KNOWN AND OBJECTIVE: Invasive fungal infections often occur in patients with comorbidities that complicate oral administration. Serum concentrations of isavuconazole were characterized after enteral tube administration. CASE DESCRIPTION: Thirteen of 14 isavuconazole concentrations were >1 mg/dl (median 1.6 mg/dl) among those receiving enteral tube administration, which was comparable to intravenous (median 1.9 mg/dl). Higher concentrations were observed during oral administration (median 3 mg/dl). WHAT IS NEW AND CONCLUSION: Administration of isavuconazole via tube resulted in concentrations comparable to FDA-approved routes of administration. This route may be feasible and appropriate for select patients.

Full Text

Duke Authors

Cited Authors

  • Spivey, J; Wrenn, R; Liu, B; Maziarz, E; Kram, B

Published Date

  • April 2021

Published In

Volume / Issue

  • 46 / 2

Start / End Page

  • 528 - 531

PubMed ID

  • 33247433

Pubmed Central ID

  • PMC7969444

Electronic International Standard Serial Number (EISSN)

  • 1365-2710

Digital Object Identifier (DOI)

  • 10.1111/jcpt.13317


  • eng

Conference Location

  • England