Effective control of SARS-CoV-2 transmission in Wanzhou, China.

Journal Article (Journal Article)

The effectiveness of control measures to contain coronavirus disease 2019 (COVID-19) in Wanzhou, China was assessed. Epidemiological data were analyzed for 183 confirmed COVID-19 cases and their close contacts from five generations of transmission of severe acute respiratory syndrome coronavirus 2 throughout the entire COVID-19 outbreak in Wanzhou. Approximately 67.2% and 32.8% of cases were symptomatic and asymptomatic, respectively. Asymptomatic and presymptomatic transmission accounted for 75.9% of the total recorded transmission. The reproductive number was 1.64 (95% confidence interval: 1.16-2.40) for G1-to-G2 transmission, decreasing to 0.31-0.39 in later generations, concomitant with implementation of rigorous control measures. Substantially higher infection risk was associated with contact within 5 d after the infectors had been infected, frequent contact and ≥8 h of contact duration. The spread of COVID-19 was effectively controlled in Wanzhou by breaking the transmission chain through social distancing, extensive contact tracing, mass testing and strict quarantine of close contacts.

Full Text

Duke Authors

Cited Authors

  • Shi, Q; Hu, Y; Peng, B; Tang, X-J; Wang, W; Su, K; Luo, C; Wu, B; Zhang, F; Zhang, Y; Anderson, B; Zhong, X-N; Qiu, J-F; Yang, CY; Huang, A-L

Published Date

  • January 2021

Published In

Volume / Issue

  • 27 / 1

Start / End Page

  • 86 - 93

PubMed ID

  • 33257893

Electronic International Standard Serial Number (EISSN)

  • 1546-170X

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/s41591-020-01178-5


  • eng