Insight into the Mode of Action of Haedoxan A from Phryma leptostachya.

Journal Article (Journal Article)

Haedoxan A (HA) is a major active ingredient in the herbaceous perennial plant lopseed (Phryma leptostachya L.), which is used as a natural insecticide against insect pests in East Asia. Here, we report that HA delayed the decay rate of evoked excitatory junctional potentials (EJPs) and increased the frequency of miniature EJPs (mEJPs) on the Drosophila neuromuscular junction. HA also caused a significant hyperpolarizing shift of the voltage dependence of fast inactivation of insect sodium channels expressed in Xenopus oocytes. Our results suggest that HA acts on both axonal conduction and synaptic transmission, which can serve as a basis for elucidating the mode of action of HA for further designing and developing new effective insecticides.

Full Text

Duke Authors

Cited Authors

  • Hu, Z; Du, Y; Xiao, X; Dong, K; Wu, W

Published Date

  • February 2016

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 53 -

PubMed ID

  • 26907348

Pubmed Central ID

  • PMC4773806

Electronic International Standard Serial Number (EISSN)

  • 2072-6651

International Standard Serial Number (ISSN)

  • 2072-6651

Digital Object Identifier (DOI)

  • 10.3390/toxins8020053


  • eng