Sodium Channel Mutations and Pyrethroid Resistance in Aedes aegypti.

Journal Article (Review;Journal Article)

Pyrethroid insecticides are widely used to control insect pests and human disease vectors. Voltage-gated sodium channels are the primary targets of pyrethroid insecticides. Mutations in the sodium channel have been shown to be responsible for pyrethroid resistance, known as knockdown resistance (kdr), in various insects including mosquitoes. In Aedes aegypti mosquitoes, the principal urban vectors of dengue, zika, and yellow fever viruses, multiple single nucleotide polymorphisms in the sodium channel gene have been found in pyrethroid-resistant populations and some of them have been functionally confirmed to be responsible for kdr in an in vitro expression system, Xenopus oocytes. This mini-review aims to provide an update on the identification and functional characterization of pyrethroid resistance-associated sodium channel mutations from Aedes aegypti. The collection of kdr mutations not only helped us develop molecular markers for resistance monitoring, but also provided valuable information for computational molecular modeling of pyrethroid receptor sites on the sodium channel.

Full Text

Duke Authors

Cited Authors

  • Du, Y; Nomura, Y; Zhorov, BS; Dong, K

Published Date

  • October 31, 2016

Published In

Volume / Issue

  • 7 / 4

Start / End Page

  • E60 -

PubMed ID

  • 27809228

Pubmed Central ID

  • PMC5198208

Electronic International Standard Serial Number (EISSN)

  • 2075-4450

International Standard Serial Number (ISSN)

  • 2075-4450

Digital Object Identifier (DOI)

  • 10.3390/insects7040060


  • eng