COVID-19 in solid organ transplant recipients: A systematic review and meta-analysis of current literature.

Journal Article (Journal Article;Systematic Review)

Severe acute respiratory virus syndrome 2 (SARS-CoV-2) has led to a worldwide pandemic. Early studies in solid organ transplant (SOT) recipients suggested a wide variety of presentations, however, there remains a paucity of robust data in this population. We conducted a systematic review and meta-analysis of SOT recipients with SARS-CoV-2 infection from January 1st t October 9th, 2020. Pooled incidence of symptoms, treatments and outcomes were assessed. Two hundred and fifteen studies were included for systematic review and 60 for meta-analysis. We identified 2,772 unique SOT recipients including 1,500 kidney, 505 liver, 141 heart and 97 lung. Most common presenting symptoms were fever and cough in 70.2% and 63.8% respectively. Majority (81%) required hospital admission. Immunosuppressive medications, especially antimetabolites, were decreased in 76.2%. Hydroxychloroquine and interleukin six antagonists were administered in59.5% and 14.9% respectively, while only few patients received remdesivir and convalescent plasma. Intensive care unit admission was 29% from amongst hospitalized patients. Only few studies reported secondary infections. Overall mortality was 18.6%. Our analysis shows a high incidence of hospital admission in SOT recipients with SARS-CoV-2 infection. As management of SARS-CoV-2 continues to evolve, long-term outcomes among SOT recipients should be assessed in future studies.

Full Text

Duke Authors

Cited Authors

  • Raja, MA; Mendoza, MA; Villavicencio, A; Anjan, S; Reynolds, JM; Kittipibul, V; Fernandez, A; Guerra, G; Camargo, JF; Simkins, J; Morris, MI; Abbo, LA; Natori, Y

Published Date

  • January 2021

Published In

Volume / Issue

  • 35 / 1

Start / End Page

  • 100588 -

PubMed ID

  • 33246166

Pubmed Central ID

  • PMC7666542

Electronic International Standard Serial Number (EISSN)

  • 1557-9816

Digital Object Identifier (DOI)

  • 10.1016/j.trre.2020.100588

Language

  • eng

Conference Location

  • United States