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Further understanding the connection between Alzheimer's disease and Down syndrome.

Publication ,  Journal Article
Snyder, HM; Bain, LJ; Brickman, AM; Carrillo, MC; Esbensen, AJ; Espinosa, JM; Fernandez, F; Fortea, J; Hartley, SL; Head, E; Hendrix, J ...
Published in: Alzheimers Dement
July 2020

Improved medical care of individuals with Down syndrome (DS) has led to an increase in life expectancy to over the age of 60 years. In conjunction, there has been an increase in age-related co-occurring conditions including Alzheimer's disease (AD). Understanding the factors that underlie symptom and age of clinical presentation of dementia in people with DS may provide insights into the mechanisms of sporadic and DS-associated AD (DS-AD). In March 2019, the Alzheimer's Association, Global Down Syndrome Foundation and the LuMind IDSC Foundation partnered to convene a workshop to explore the state of the research on the intersection of AD and DS research; to identify research gaps and unmet needs; and to consider how best to advance the field. This article provides a summary of discussions, including noting areas of emerging science and discovery, considerations for future studies, and identifying open gaps in our understanding for future focus.

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Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

July 2020

Volume

16

Issue

7

Start / End Page

1065 / 1077

Location

United States

Related Subject Headings

  • Humans
  • Geriatrics
  • Down Syndrome
  • Amyloid beta-Peptides
  • Alzheimer Disease
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

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Chicago
ICMJE
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Snyder, H. M., Bain, L. J., Brickman, A. M., Carrillo, M. C., Esbensen, A. J., Espinosa, J. M., … Rafii, M. S. (2020). Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimers Dement, 16(7), 1065–1077. https://doi.org/10.1002/alz.12112
Snyder, Heather M., Lisa J. Bain, Adam M. Brickman, Maria C. Carrillo, Anna J. Esbensen, Joaquin M. Espinosa, Fabian Fernandez, et al. “Further understanding the connection between Alzheimer's disease and Down syndrome.Alzheimers Dement 16, no. 7 (July 2020): 1065–77. https://doi.org/10.1002/alz.12112.
Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, et al. Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimers Dement. 2020 Jul;16(7):1065–77.
Snyder, Heather M., et al. “Further understanding the connection between Alzheimer's disease and Down syndrome.Alzheimers Dement, vol. 16, no. 7, July 2020, pp. 1065–77. Pubmed, doi:10.1002/alz.12112.
Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, Mobley W, Mufson EJ, Potter H, Zaman SH, Granholm A-C, Rosas HD, Strydom A, Whitten MS, Rafii MS. Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimers Dement. 2020 Jul;16(7):1065–1077.
Journal cover image

Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

July 2020

Volume

16

Issue

7

Start / End Page

1065 / 1077

Location

United States

Related Subject Headings

  • Humans
  • Geriatrics
  • Down Syndrome
  • Amyloid beta-Peptides
  • Alzheimer Disease
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences