Management of hemostatic complications in acute leukemia: Guidance from the SSC of the ISTH.

Journal Article (Journal Article)

Patients with acute leukemia frequently develop thrombocytopenia and hemostatic complications caused by coagulopathy. Coagulopathy complicates the management of these patients and can lead to significant morbidity and mortality. This guidance document aims to review and provide guidance on the management of hemostatic complications in adult patients with acute leukemia, addressing four main issues, including platelet transfusion, disseminated intravascular coagulation, L-asparaginase-related hypofibrinogenemia, and the use of antifibrinolytic agents.

Full Text

Duke Authors

Cited Authors

  • Wang, T-F; Makar, RS; Antic, D; Levy, JH; Douketis, JD; Connors, JM; Carrier, M; Zwicker, JI

Published Date

  • December 2020

Published In

Volume / Issue

  • 18 / 12

Start / End Page

  • 3174 - 3183

PubMed ID

  • 33433069

Pubmed Central ID

  • PMC7909744

Electronic International Standard Serial Number (EISSN)

  • 1538-7836

Digital Object Identifier (DOI)

  • 10.1111/jth.15074


  • eng

Conference Location

  • England