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Association of low blood arsenic exposure with level of malondialdehyde among Chinese adults aged 65 and older.

Publication ,  Journal Article
Tan, Q; Lv, Y; Zhao, F; Zhou, J; Yang, Y; Liu, Y; Zhang, M; Lu, F; Wei, Y; Chen, X; Zhang, R; Chen, C; Wu, B; Zhang, X; Li, C; Huang, H ...
Published in: The Science of the total environment
March 2021

High environmental arsenic exposure can increase chronic oxidative stress in experimental studies and in occupational epidemiology studies. Many regulatory agencies have put forth arsenic exposure limits, it is still unclear that whether low environmental arsenic exposure was associated with adverse health outcome in general population. This study aimed to explore the association of low blood arsenic with malondialdehyde in community-dwelling older adults. We used a cross-sectional study of 2384 older adult individuals aged ≥65 years (mean age: 85 years) from the Healthy Aging and Biomarkers Cohort Study in 2017. The median blood arsenic level was 1.41 μg/L. High oxidative stress was categorized according to the 95th percentile of MDA levels (7.47 nmol/mL). Restricted cubic spline models showed that blood arsenic levels were positively associated with malondialdehyde levels (P < 0.01); and the risk of high oxidative stress was no longer significantly increased when blood arsenic level up to 8.74 μg/L. After adjusting for potential confounders, the odds ratios of high oxidative stress for the second, third, and fourth quartiles of blood arsenic were 2.35 (1.11-4.96), 3.87 (1.90-7.91), and 4.18 (2.00-8.72) (Ptrend < 0.01), compared with the first quartile. We concluded that even low arsenic exposure was associated with higher risk of oxidative stress, in a nonlinear dose-response.

Duke Scholars

Published In

The Science of the total environment

DOI

EISSN

1879-1026

ISSN

0048-9697

Publication Date

March 2021

Volume

758

Start / End Page

143638

Related Subject Headings

  • Malondialdehyde
  • Humans
  • Environmental Sciences
  • Environmental Exposure
  • Cross-Sectional Studies
  • Cohort Studies
  • Asian People
  • Arsenic
  • Aged, 80 and over
  • Aged
 

Citation

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Tan, Q., Lv, Y., Zhao, F., Zhou, J., Yang, Y., Liu, Y., … Shi, X. (2021). Association of low blood arsenic exposure with level of malondialdehyde among Chinese adults aged 65 and older. The Science of the Total Environment, 758, 143638. https://doi.org/10.1016/j.scitotenv.2020.143638
Tan, Qiyue, Yuebin Lv, Feng Zhao, Jinhui Zhou, Yang Yang, Yingchun Liu, Mingyuan Zhang, et al. “Association of low blood arsenic exposure with level of malondialdehyde among Chinese adults aged 65 and older.The Science of the Total Environment 758 (March 2021): 143638. https://doi.org/10.1016/j.scitotenv.2020.143638.
Tan Q, Lv Y, Zhao F, Zhou J, Yang Y, Liu Y, et al. Association of low blood arsenic exposure with level of malondialdehyde among Chinese adults aged 65 and older. The Science of the total environment. 2021 Mar;758:143638.
Tan, Qiyue, et al. “Association of low blood arsenic exposure with level of malondialdehyde among Chinese adults aged 65 and older.The Science of the Total Environment, vol. 758, Mar. 2021, p. 143638. Epmc, doi:10.1016/j.scitotenv.2020.143638.
Tan Q, Lv Y, Zhao F, Zhou J, Yang Y, Liu Y, Zhang M, Lu F, Wei Y, Chen X, Zhang R, Chen C, Wu B, Zhang X, Li C, Huang H, Cai J, Cao Z, Yu D, Ji JS, Zhao S, Shi X. Association of low blood arsenic exposure with level of malondialdehyde among Chinese adults aged 65 and older. The Science of the total environment. 2021 Mar;758:143638.
Journal cover image

Published In

The Science of the total environment

DOI

EISSN

1879-1026

ISSN

0048-9697

Publication Date

March 2021

Volume

758

Start / End Page

143638

Related Subject Headings

  • Malondialdehyde
  • Humans
  • Environmental Sciences
  • Environmental Exposure
  • Cross-Sectional Studies
  • Cohort Studies
  • Asian People
  • Arsenic
  • Aged, 80 and over
  • Aged