Controlled release of etoricoxib from poly(ester urea) films for post-operative pain management.

Journal Article (Journal Article)

Medical prescriptions for the alleviation of post-surgical pain are the most abundant source of opioids in circulation. As a systemic drug delivery source, opioids leave patients at high risk for side effects after being dosed. Given the significant rate of unauthorized use, distribution, addiction, and opioid related deaths, an alternative method of post-surgical analgesia is needed. Herein, we report the use of bio-resorbable poly(ester urea) (PEU) films that controllably deliver a non-opioid COX-2 inhibitor, etoricoxib, in vivo and in vitro as a model system for post-surgical pain control. PEU composition, drug-load, and film thickness were varied to selectively control etoricoxib elution. Elution data were fit to a Higuchi model, and the diffusion constant of etoricoxib was calculated in each of the films. Pharmacokinetic (pK) data from an in vivo rat model showed the local tissue concentration of etoricoxib at the study endpoint to be up to 23-fold higher in tissue then plasma. In a well-established mouse model of diabetic neuropathic pain in vivo film implantation showed effective relief of pain for more than 4 days post-implantation and efficacious local etoricoxib delivery. Overall, implementation of local drug delivery systems such as this could reduce the need for opioid prescriptions associated with current pain management strategies.

Full Text

Duke Authors

Cited Authors

  • Brigham, NC; Nofsinger, R; Luo, X; Dreger, NZ; Abel, AK; Gustafson, TP; Forster, SP; Hermans, A; Ji, R-R; Becker, ML

Published Date

  • January 10, 2021

Published In

Volume / Issue

  • 329 /

Start / End Page

  • 316 - 327

PubMed ID

  • 33278481

Electronic International Standard Serial Number (EISSN)

  • 1873-4995

Digital Object Identifier (DOI)

  • 10.1016/j.jconrel.2020.11.052

Language

  • eng

Conference Location

  • Netherlands