Heparin-Induced Thrombocytopenia: A Focus on Thrombosis.

Journal Article (Journal Article;Review)

Heparin-induced thrombocytopenia is an immune-mediated disorder caused by antibodies that recognize complexes of platelet factor 4 and heparin. Thrombosis is a central and unpredictable feature of this syndrome. Despite optimal management, disease morbidity and mortality from thrombosis remain high. The hypercoagulable state in heparin-induced thrombocytopenia is biologically distinct from other thrombophilic disorders in that clinical complications are directly attributable to circulating ultra-large immune complexes. In some individuals, ultra-large immune complexes elicit unchecked cellular procoagulant responses that culminate in thrombosis. To date, the clinical and biologic risk factors associated with thrombotic risk in heparin-induced thrombocytopenia remain elusive. This review will summarize our current understanding of thrombosis in heparin-induced thrombocytopenia with attention to its clinical features, cellular mechanisms, and its management.

Full Text

Duke Authors

Cited Authors

  • Arepally, GM; Padmanabhan, A

Published Date

  • January 2021

Published In

Volume / Issue

  • 41 / 1

Start / End Page

  • 141 - 152

PubMed ID

  • 33267665

Pubmed Central ID

  • PMC7769912

Electronic International Standard Serial Number (EISSN)

  • 1524-4636

Digital Object Identifier (DOI)

  • 10.1161/ATVBAHA.120.315445


  • eng

Conference Location

  • United States