Feasibility of Mild Traumatic Brain Injury Assessment Based on Cardiovascular Response to Postural Change.

Journal Article (Journal Article)


To determine the feasibility of short-term cardiovascular responses to postural change as a screening tool for mild traumatic brain injury (mTBI), using heart rate metrics that can be measured with a wearable electrocardiogram sensor.


Military TBI clinic.


Data collected from active-duty service members who had sustained a medically diagnosed mTBI within the prior 72 hours and from age- and sex-matched controls. Cardiac data collected while participants performed a sequence of postural changes.

Main measures

Model classification compared with clinical mTBI diagnosis.


Cardiac biomarkers of mTBI were identified and logistic regression classifiers for mTBI were developed from different subsets of biomarkers. The best model achieved 90% sensitivity and 69% specificity using data from 2 different postural changes.


Noninvasive measurement of cardiovascular response to postural change is a promising approach for field-deployable post-mTBI screening.

Full Text

Duke Authors

Cited Authors

  • Russell, KN; Preble, EA; Hegarty-Craver, M; Arrieux, JP; Cole, WR; Choi, YS; Grego, S; Rae Olmsted, K; Gilchrist, KH

Published Date

  • September 2020

Published In

Volume / Issue

  • 35 / 5

Start / End Page

  • E422 - E428

PubMed ID

  • 32472839

Electronic International Standard Serial Number (EISSN)

  • 1550-509X

International Standard Serial Number (ISSN)

  • 0885-9701

Digital Object Identifier (DOI)

  • 10.1097/htr.0000000000000582


  • eng