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Lipid-based Vehicles for siRNA Delivery in Biomedical Field.

Publication ,  Journal Article
Li, T; Huang, L; Yang, M
Published in: Current pharmaceutical biotechnology
January 2020

Genetic drugs have aroused much attention in the past twenty years. RNA interference (RNAi) offers novel insights into discovering potential gene functions and therapies targeting genetic diseases. Small interference RNA (siRNA), typically 21-23 nucleotides in length, can specifically degrade complementary mRNA. However, targeted delivery and controlled release of siRNA remain a great challenge.Different types of lipid-based delivery vehicles have been synthesized, such as liposomes, lipidoids, micelles, lipoplexes and lipid nanoparticles. These carriers commonly have a core-shell structure. For active targeting, ligands may be conjugated to the surface of lipid particles.Lipid-based drug delivery vehicles can be utilized in anti-viral or anti-tumor therapies. They can also be used to tackle genetic diseases or discover novel druggable genes.In this review, the structures of lipid-based vehicles and possible surface modifications are described, and applications of delivery vehicles in biomedical field are discussed.

Duke Scholars

Published In

Current pharmaceutical biotechnology

DOI

EISSN

1873-4316

ISSN

1389-2010

Publication Date

January 2020

Volume

21

Issue

1

Start / End Page

3 / 22

Related Subject Headings

  • RNA, Small Interfering
  • Lipids
  • Humans
  • Biotechnology
  • Biomedical Technology
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3206 Medical biotechnology
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1004 Medical Biotechnology
 

Citation

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MLA
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Li, T., Huang, L., & Yang, M. (2020). Lipid-based Vehicles for siRNA Delivery in Biomedical Field. Current Pharmaceutical Biotechnology, 21(1), 3–22. https://doi.org/10.2174/1389201020666190924164152
Li, Tianzhong, Linfeng Huang, and Mengsu Yang. “Lipid-based Vehicles for siRNA Delivery in Biomedical Field.Current Pharmaceutical Biotechnology 21, no. 1 (January 2020): 3–22. https://doi.org/10.2174/1389201020666190924164152.
Li T, Huang L, Yang M. Lipid-based Vehicles for siRNA Delivery in Biomedical Field. Current pharmaceutical biotechnology. 2020 Jan;21(1):3–22.
Li, Tianzhong, et al. “Lipid-based Vehicles for siRNA Delivery in Biomedical Field.Current Pharmaceutical Biotechnology, vol. 21, no. 1, Jan. 2020, pp. 3–22. Epmc, doi:10.2174/1389201020666190924164152.
Li T, Huang L, Yang M. Lipid-based Vehicles for siRNA Delivery in Biomedical Field. Current pharmaceutical biotechnology. 2020 Jan;21(1):3–22.

Published In

Current pharmaceutical biotechnology

DOI

EISSN

1873-4316

ISSN

1389-2010

Publication Date

January 2020

Volume

21

Issue

1

Start / End Page

3 / 22

Related Subject Headings

  • RNA, Small Interfering
  • Lipids
  • Humans
  • Biotechnology
  • Biomedical Technology
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 3206 Medical biotechnology
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1004 Medical Biotechnology