Analyses on mutation patterns, detection of population bottlenecks, and suggestion of deleterious-compensatory evolution among members of the genus Potyvirus.

Journal Article (Journal Article)

Viruses of the family Potyviridae exhibited a robust single-nucleotide polymorphism profile at the between-species level, conforming to the neutral theory rule. However, the ratios of nonsynonymous to synonymous mutations (Ka/Ks) were relatively greater between-species than within-species in viral cistrons examined from members of the genus Potyvirus, indicating a relaxation on constraint. Judged by the McDonald and Kreitman's test, the fixation frequencies for nonsynonymous mutations across the genomes of closely related potyviruses were greater than expected, suggesting population bottlenecks at speciation. These mutation patterns are best explained by a deleterious-compensatory model.

Full Text

Duke Authors

Cited Authors

  • Wang, H; Huang, LF; Cooper, JI

Published Date

  • August 2006

Published In

Volume / Issue

  • 151 / 8

Start / End Page

  • 1625 - 1633

PubMed ID

  • 16538419

Electronic International Standard Serial Number (EISSN)

  • 1432-8798

International Standard Serial Number (ISSN)

  • 0304-8608

Digital Object Identifier (DOI)

  • 10.1007/s00705-006-0741-z


  • eng