An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II.

Journal Article (Journal Article)

Genetic evidence indicates that plant-specific homologs of DNA-dependent RNA polymerase (Pol) II large subunits form Pol IV and Pol V complexes involved in small interfering RNA production and RNA-directed DNA methylation. Here we describe evidence that Pol V contains subunits shared with Pol II, but that RNA polymerase II subunit (RPB)-4 is missing from Pol V and that RPB5 is present as a Pol V-specific isomer, RPB5b. Pol V also has other proteins that are not present in Pol II, consistent with a role of this complex as an effector of silencing.

Full Text

Duke Authors

Cited Authors

  • Huang, L; Jones, AME; Searle, I; Patel, K; Vogler, H; Hubner, NC; Baulcombe, DC

Published Date

  • January 2009

Published In

Volume / Issue

  • 16 / 1

Start / End Page

  • 91 - 93

PubMed ID

  • 19079263

Electronic International Standard Serial Number (EISSN)

  • 1545-9985

International Standard Serial Number (ISSN)

  • 1545-9993

Digital Object Identifier (DOI)

  • 10.1038/nsmb.1539


  • eng