Prostate Cancer Foundation Hormone-Sensitive Prostate Cancer Biomarker Working Group Meeting Summary.

Journal Article (Journal Article;Review)

Androgen deprivation therapy remains the backbone therapy for the treatment of metastatic hormone-sensitive prostate cancer (mHSPC). In recent years, several treatments, including docetaxel, abiraterone + prednisone, enzalutamide, and apalutamide, have each been shown to demonstrate survival benefit when used upfront along with androgen deprivation therapy. However, treatment selection for an individual patient remains a challenge. There is no high level clinical evidence for treatment selection among these choices based on biological drivers of clinical disease. In August 2020, the Prostate Cancer Foundation convened a working group to meet and discuss biomarkers for hormone-sensitive prostate cancer, the proceedings of which are summarized here. This meeting covered the state of clinical and biological evidence for systemic therapies in the mHSPC space, with emphasis on charting a course for the generation, interrogation, and clinical implementation of biomarkers for treatment selection.

Full Text

Duke Authors

Cited Authors

  • Hofmann, MR; Hussain, M; Dehm, SM; Beltran, H; Wyatt, AW; Halabi, S; Sweeney, C; Scher, HI; Ryan, CJ; Feng, FY; Attard, G; Klein, E; Miyahira, AK; Soule, HR; Sharifi, N

Published Date

  • December 26, 2020

Published In

PubMed ID

  • 33373705

Electronic International Standard Serial Number (EISSN)

  • 1527-9995

Digital Object Identifier (DOI)

  • 10.1016/j.urology.2020.12.021

Language

  • eng

Conference Location

  • United States