Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer.

Journal Article (Journal Article)

DNA polymerase mutations can cause hypermutant cancers, but the mechanisms of tumorigenesis and the impact of various DNA polymerase mutations on treatment response is poorly understood. In this issue of Cancer Research, Galati and colleagues investigate the effects of cancer-associated DNA polymerase ϵ (Pole) mutations on tumorigenesis and response to immune checkpoint blockade. They describe novel genetically engineered mouse models harboring cancer-associated Pole mutations and examine the effects of these mutations on tumorigenesis, the tumor mutational landscape, and the tumor immune microenvironment. Integrating this information with an emerging understanding of how different tumor mutations influence the response to immunotherapy may aid in prediction, diagnosis, and treatment of Pole-mutant tumors.See related article by Galati et al., p. 5606.

Full Text

Duke Authors

Cited Authors

  • Wisdom, AJ; Kirsch, DG

Published Date

  • December 15, 2020

Published In

Volume / Issue

  • 80 / 24

Start / End Page

  • 5459 - 5461

PubMed ID

  • 33323408

Pubmed Central ID

  • PMC7931142

Electronic International Standard Serial Number (EISSN)

  • 1538-7445

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.CAN-20-3241


  • eng

Conference Location

  • United States