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Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration.

Publication ,  Journal Article
Shen, LL; Sun, M; Ahluwalia, A; Park, MM; Young, BK; Lad, EM; Toth, C; Del Priore, LV
Published in: Br J Ophthalmol
May 2022

BACKGROUND: The macular central 1 mm diameter zone is crucial to patients' visual acuity, but the long-term natural history of central sparing in eyes with geographic atrophy (GA) is unknown. METHODS: We manually segmented GA in 210 eyes with GA involving central 1 mm diameter zone (mean follow-up=3.8 years) in the Age-Related Eye Disease Study. We measured the residual area in central 1 mm diameter zone and calculated central residual effective radius (CRER) as square root of (residual area/π). A linear mixed-effects model was used to model residual size over time. We added a horizontal translation factor to each data set to account for different durations of GA involving the central zone. RESULTS: The decline rate of central residual area was associated with baseline residual area (p=0.008), but a transformation from central residual area to CRER eliminated this relationship (p=0.51). After the introduction of horizontal translation factors to each data set, CRER declined linearly over approximately 13 years (r2=0.80). The growth rate of total GA effective radius was 0.14 mm/year (95% CI 0.12 to 0.15), 3.7-fold higher than the decline rate of CRER (0.038 mm/year, 95% CI 0.034 to 0.042). The decline rate of CRER was 53.3% higher in eyes with than without advanced age-related macular degeneration in the fellow eyes at any visit (p=0.007). CONCLUSIONS: CRER in eyes with GA declined linearly over approximately 13 years and may serve as an anatomic endpoint in future clinical trials aiming to preserve the central zone.

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Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

May 2022

Volume

106

Issue

5

Start / End Page

689 / 695

Location

England

Related Subject Headings

  • Visual Acuity
  • Ophthalmology & Optometry
  • Macular Degeneration
  • Humans
  • Geographic Atrophy
  • Fundus Oculi
  • Follow-Up Studies
  • Fluorescein Angiography
  • Disease Progression
  • Atrophy
 

Citation

APA
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MLA
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Shen, L. L., Sun, M., Ahluwalia, A., Park, M. M., Young, B. K., Lad, E. M., … Del Priore, L. V. (2022). Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration. Br J Ophthalmol, 106(5), 689–695. https://doi.org/10.1136/bjophthalmol-2020-317636
Shen, Liangbo L., Mengyuan Sun, Aneesha Ahluwalia, Michael M. Park, Benjamin K. Young, Eleonora M. Lad, Cynthia Toth, and Lucian V. Del Priore. “Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration.Br J Ophthalmol 106, no. 5 (May 2022): 689–95. https://doi.org/10.1136/bjophthalmol-2020-317636.
Shen LL, Sun M, Ahluwalia A, Park MM, Young BK, Lad EM, et al. Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration. Br J Ophthalmol. 2022 May;106(5):689–95.
Shen, Liangbo L., et al. “Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration.Br J Ophthalmol, vol. 106, no. 5, May 2022, pp. 689–95. Pubmed, doi:10.1136/bjophthalmol-2020-317636.
Shen LL, Sun M, Ahluwalia A, Park MM, Young BK, Lad EM, Toth C, Del Priore LV. Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration. Br J Ophthalmol. 2022 May;106(5):689–695.

Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

May 2022

Volume

106

Issue

5

Start / End Page

689 / 695

Location

England

Related Subject Headings

  • Visual Acuity
  • Ophthalmology & Optometry
  • Macular Degeneration
  • Humans
  • Geographic Atrophy
  • Fundus Oculi
  • Follow-Up Studies
  • Fluorescein Angiography
  • Disease Progression
  • Atrophy