Antibody response and therapy in COVID-19 patients: what can be learned for vaccine development?
Journal Article (Journal Article;Review)
The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people and caused tremendous morbidity and mortality worldwide. Effective treatment for coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 infection is lacking, and different therapeutic strategies are under testing. Host humoral and cellular immunity to SARS-CoV-2 infection is a critical determinant for patients' outcomes. SARS-CoV-2 infection results in seroconversion and production of anti-SARS-CoV-2 antibodies. The antibodies may suppress viral replication through neutralization but might also participate in COVID-19 pathogenesis through a process termed antibody-dependent enhancement. Rapid progress has been made in the research of antibody response and therapy in COVID-19 patients, including characterization of the clinical features of antibody responses in different populations infected by SARS-CoV-2, treatment of COVID-19 patients with convalescent plasma and intravenous immunoglobin products, isolation and characterization of a large panel of monoclonal neutralizing antibodies and early clinical testing, as well as clinical results from several COVID-19 vaccine candidates. In this review, we summarize the recent progress and discuss the implications of these findings in vaccine development.
Full Text
Duke Authors
Cited Authors
- Lu, L; Zhang, H; Zhan, M; Jiang, J; Yin, H; Dauphars, DJ; Li, S-Y; Li, Y; He, Y-W
Published Date
- December 2020
Published In
Volume / Issue
- 63 / 12
Start / End Page
- 1833 - 1849
PubMed ID
- 33355886
Pubmed Central ID
- 33355886
Electronic International Standard Serial Number (EISSN)
- 1869-1889
Digital Object Identifier (DOI)
- 10.1007/s11427-020-1859-y
Language
- eng
Conference Location
- China