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Intranasal Subunit Vaccination Strategies Employing Nanomaterials and Biomaterials.

Publication ,  Journal Article
Cossette, B; Kelly, SH; Collier, JH
Published in: ACS biomaterials science & engineering
May 2021

Intranasal vaccines offer key advantages over traditional needle-based vaccines. They are simple to administer and painless and establish local immunity at mucosal surfaces. Owing to these advantages, they are particularly attractive for use in resource-limited locations of the world. Subunit vaccines also have advantages for global distribution, as they can be engineered to be more stable to fluctuations in environmental conditions than live-attenuated or inactivated vaccines, but they tend to be poorly immunogenic intranasally. Toward realizing the potential of intranasal subunit vaccination, biomaterial-based technologies are emerging. This review provides an overview of recent progress in the preclinical development of biomaterial-based intranasal vaccines against subunit antigens and should serve as an effective introduction to the current state of this exciting field. We provide a brief overview of the obstacles facing intranasal vaccine development and identify key design criteria for consideration when designing biomaterials for intranasal subunit vaccine delivery. Promising strategies are discussed across a wide array of biomaterial classes, with a focus on selected exemplary works that highlight the considerable potential of intranasal vaccines and the biomaterial-based technologies that enable them.

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Published In

ACS biomaterials science & engineering

DOI

EISSN

2373-9878

ISSN

2373-9878

Publication Date

May 2021

Volume

7

Issue

5

Start / End Page

1765 / 1779

Related Subject Headings

  • Vaccines, Subunit
  • Vaccination
  • Nanostructures
  • Influenza Vaccines
  • Biocompatible Materials
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
 

Citation

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Cossette, B., Kelly, S. H., & Collier, J. H. (2021). Intranasal Subunit Vaccination Strategies Employing Nanomaterials and Biomaterials. ACS Biomaterials Science & Engineering, 7(5), 1765–1779. https://doi.org/10.1021/acsbiomaterials.0c01291
Cossette, Benjamin, Sean H. Kelly, and Joel H. Collier. “Intranasal Subunit Vaccination Strategies Employing Nanomaterials and Biomaterials.ACS Biomaterials Science & Engineering 7, no. 5 (May 2021): 1765–79. https://doi.org/10.1021/acsbiomaterials.0c01291.
Cossette B, Kelly SH, Collier JH. Intranasal Subunit Vaccination Strategies Employing Nanomaterials and Biomaterials. ACS biomaterials science & engineering. 2021 May;7(5):1765–79.
Cossette, Benjamin, et al. “Intranasal Subunit Vaccination Strategies Employing Nanomaterials and Biomaterials.ACS Biomaterials Science & Engineering, vol. 7, no. 5, May 2021, pp. 1765–79. Epmc, doi:10.1021/acsbiomaterials.0c01291.
Cossette B, Kelly SH, Collier JH. Intranasal Subunit Vaccination Strategies Employing Nanomaterials and Biomaterials. ACS biomaterials science & engineering. 2021 May;7(5):1765–1779.
Journal cover image

Published In

ACS biomaterials science & engineering

DOI

EISSN

2373-9878

ISSN

2373-9878

Publication Date

May 2021

Volume

7

Issue

5

Start / End Page

1765 / 1779

Related Subject Headings

  • Vaccines, Subunit
  • Vaccination
  • Nanostructures
  • Influenza Vaccines
  • Biocompatible Materials
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering