Scholars@Duke publication: Completeness and concordancy of WHO grade assignment for brain and central nervous system tumors in the United States, 2004-2011.

Completeness and concordancy of WHO grade assignment for brain and central nervous system tumors in the United States, 2004-2011.

Publication , Journal Article

Lym, RL; Ostrom, QT; Kruchko, C; Couce, M; Brat, DJ; Louis, DN; Barnholtz-Sloan, JS

Published in: J Neurooncol

May 2015

Central nervous system (CNS) tumors are categorized and graded for clinical and research purposes according to the World Health Organization (WHO) scheme which segregates tumors by histological type and predicted biological behavior. However, reporting of WHO grade in pathological reports is inconsistent despite its collection in cancer registration. We studied the completeness, concordancy, and yearly trends in the collection of WHO grade for primary CNS tumors between 2004 and 2011. Data from the Surveillance, Epidemiology and End Results program were analyzed for the percentage of histologically diagnosed primary CNS tumor cases with concordantly documented WHO grades between 2004 and 2011. Yearly trends were calculated with annual percentage changes (APC) and 95% confidence intervals (95% CI). Completeness and concordancy of the collection of WHO grade varied significantly by histological type and year. The percentage of cases with documented WHO grade increased significantly from 2004 to 2011: 39.0% of cases in 2004 had documented WHO grade, while 77.5% of cases had documented grade in 2011 (APC, 10.3; 95% CI: 9.0, 11.5). Among cases with documented WHO grade, the percentage graded concordantly increased significantly from 89.1% in 2004 to 93.7% in 2007 (APC, 1.8; 95% CI: 1.0, 2.6) and these values varied over time by histological type. One common trend among all histologies was a significant increase in the percentage of cases with documented WHO grade. A sizeable proportion of reported CNS tumors collected by cancer registrars have undocumented WHO grade, while a much smaller proportion are graded discordantly. Data collection on grade has improved in completeness and concordancy over time. Efforts to further improve collection of this variable are essential for clinical care and the epidemiological surveillance of CNS tumors.

Duke Scholars

Author Quinn Ostrom Neurosurgery, Neuro-Oncology

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Published In

J Neurooncol

DOI

10.1007/s11060-015-1775-4

EISSN

1573-7373

Publication Date

May 2015

Volume

123

Issue

Start / End Page

43 / 51

Location

United States

Related Subject Headings

World Health Organization
United States
Time Factors
SEER Program
Prognosis
Oncology & Carcinogenesis
Neoplasm Grading
Humans
Central Nervous System Neoplasms
Brain Neoplasms

Citation

APA

Chicago

ICMJE

MLA

NLM

Lym, R. L., Ostrom, Q. T., Kruchko, C., Couce, M., Brat, D. J., Louis, D. N., & Barnholtz-Sloan, J. S. (2015). Completeness and concordancy of WHO grade assignment for brain and central nervous system tumors in the United States, 2004-2011. J Neurooncol, 123(1), 43–51. https://doi.org/10.1007/s11060-015-1775-4

Lym, Ryan L., Quinn T. Ostrom, Carol Kruchko, Marta Couce, Daniel J. Brat, David N. Louis, and Jill S. Barnholtz-Sloan. “Completeness and concordancy of WHO grade assignment for brain and central nervous system tumors in the United States, 2004-2011.” J Neurooncol 123, no. 1 (May 2015): 43–51. https://doi.org/10.1007/s11060-015-1775-4.

Lym RL, Ostrom QT, Kruchko C, Couce M, Brat DJ, Louis DN, et al. Completeness and concordancy of WHO grade assignment for brain and central nervous system tumors in the United States, 2004-2011. J Neurooncol. 2015 May;123(1):43–51.

Lym, Ryan L., et al. “Completeness and concordancy of WHO grade assignment for brain and central nervous system tumors in the United States, 2004-2011.” J Neurooncol, vol. 123, no. 1, May 2015, pp. 43–51. Pubmed, doi:10.1007/s11060-015-1775-4.

Lym RL, Ostrom QT, Kruchko C, Couce M, Brat DJ, Louis DN, Barnholtz-Sloan JS. Completeness and concordancy of WHO grade assignment for brain and central nervous system tumors in the United States, 2004-2011. J Neurooncol. 2015 May;123(1):43–51.