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Primary brain and other central nervous system tumors in Appalachia: regional differences in incidence, mortality, and survival.

Publication ,  Journal Article
Ostrom, QT; Gittleman, H; Kruchko, C; Barnholtz-Sloan, JS
Published in: J Neurooncol
March 2019

BACKGROUND: The Appalachian region is a large geographic and economic area, representing 7.69% of the United States (US). This region is more rural, whiter, older, and has a higher level of poverty as compared to the rest of the US. Limited research has been done on primary brain and other central nervous system tumors (PBT) epidemiology in this region. In this analysis we characterize incidence, mortality, and survival patterns. METHODS: Data from 2006 to 2015 were obtained from the central brain tumor registry of the US (provided by CDC and NCI). Appalachian counties were categorized using the Appalachia Regional Council scheme. Overall and histology-specific age-adjusted incidence and mortality rates per 100,000 population were generated. 1-, 5-, and 10-year relative survival (RS) was estimated using CDC national program of cancer registry data from 2001 to 2014. RESULTS: Overall PBT incidence within Appalachia was 22.62 per 100,000, which is not significantly different from the non-Appalachian US (22.77/100,000, p = 0.1189). Malignant incidence was 5% higher in Appalachia (7.55/100,000 vs. 7.23/100,000, p < 0.0001), while non-malignant incidence was 3% lower (15.07/100,000 vs. 15.54/100,000, p < 0.0001). 5-year RS for malignant PBT was lower (31.4% vs. 36.0%), and mortality due to malignant PBT was higher in Appalachia (4.86/100,000 vs. 4.34/100,000, p < 0.0001). CONCLUSION: Appalachia has increased malignant and decreased non-malignant PBT incidence, and poorer survival outcomes for malignant PBT compared to the non-Appalachian US.

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Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

March 2019

Volume

142

Issue

1

Start / End Page

27 / 38

Location

United States

Related Subject Headings

  • Young Adult
  • Survival Rate
  • Spinal Cord Neoplasms
  • Sex Factors
  • SEER Program
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Infant, Newborn
  • Infant
 

Citation

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Ostrom, Q. T., Gittleman, H., Kruchko, C., & Barnholtz-Sloan, J. S. (2019). Primary brain and other central nervous system tumors in Appalachia: regional differences in incidence, mortality, and survival. J Neurooncol, 142(1), 27–38. https://doi.org/10.1007/s11060-018-03073-z
Ostrom, Quinn T., Haley Gittleman, Carol Kruchko, and Jill S. Barnholtz-Sloan. “Primary brain and other central nervous system tumors in Appalachia: regional differences in incidence, mortality, and survival.J Neurooncol 142, no. 1 (March 2019): 27–38. https://doi.org/10.1007/s11060-018-03073-z.
Ostrom QT, Gittleman H, Kruchko C, Barnholtz-Sloan JS. Primary brain and other central nervous system tumors in Appalachia: regional differences in incidence, mortality, and survival. J Neurooncol. 2019 Mar;142(1):27–38.
Ostrom, Quinn T., et al. “Primary brain and other central nervous system tumors in Appalachia: regional differences in incidence, mortality, and survival.J Neurooncol, vol. 142, no. 1, Mar. 2019, pp. 27–38. Pubmed, doi:10.1007/s11060-018-03073-z.
Ostrom QT, Gittleman H, Kruchko C, Barnholtz-Sloan JS. Primary brain and other central nervous system tumors in Appalachia: regional differences in incidence, mortality, and survival. J Neurooncol. 2019 Mar;142(1):27–38.
Journal cover image

Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

March 2019

Volume

142

Issue

1

Start / End Page

27 / 38

Location

United States

Related Subject Headings

  • Young Adult
  • Survival Rate
  • Spinal Cord Neoplasms
  • Sex Factors
  • SEER Program
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Infant, Newborn
  • Infant