Skip to main content
Journal cover image

Sex is an important prognostic factor for glioblastoma but not for nonglioblastoma.

Publication ,  Journal Article
Gittleman, H; Ostrom, QT; Stetson, LC; Waite, K; Hodges, TR; Wright, CH; Wright, J; Rubin, JB; Berens, ME; Lathia, J; Connor, JR; Kruchko, C ...
Published in: Neurooncol Pract
December 2019

BACKGROUND: Glioblastoma (GBM) is the most common and most malignant glioma. Nonglioblastoma (non-GBM) gliomas (WHO Grades II and III) are invasive and also often fatal. The goal of this study is to determine whether sex differences exist in glioma survival. METHODS: Data were obtained from the National Cancer Database (NCDB) for years 2010 to 2014. GBM (WHO Grade IV; N = 2073) and non-GBM (WHO Grades II and III; N = 2963) were defined using the histology grouping of the Central Brain Tumor Registry of the United States. Non-GBM was divided into oligodendrogliomas/mixed gliomas and astrocytomas. Sex differences in survival were analyzed using Kaplan-Meier and multivariable Cox proportional hazards models adjusted for known prognostic variables. RESULTS: There was a female survival advantage in patients with GBM both in the unadjusted (P = .048) and adjusted (P = .003) models. Unadjusted, median survival was 20.1 months (95% CI: 18.7-21.3 months) for women and 17.8 months (95% CI: 16.9-18.7 months) for men. Adjusted, median survival was 20.4 months (95% CI: 18.9-21.6 months) for women and 17.5 months (95% CI: 16.7-18.3 months) for men. When stratifying by age group (18-55 vs 56+ years at diagnosis), this female survival advantage appeared only in the older group, adjusting for covariates (P = .017). Women (44.1%) had a higher proportion of methylated MGMT (O6-methylguanine-DNA methyltransferase) than men (38.4%). No sex differences were found for non-GBM. CONCLUSIONS: Using the NCDB data, there was a statistically significant female survival advantage in GBM, but not in non-GBM.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Neurooncol Pract

DOI

ISSN

2054-2577

Publication Date

December 2019

Volume

6

Issue

6

Start / End Page

451 / 462

Location

England
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gittleman, H., Ostrom, Q. T., Stetson, L. C., Waite, K., Hodges, T. R., Wright, C. H., … Barnholtz-Sloan, J. S. (2019). Sex is an important prognostic factor for glioblastoma but not for nonglioblastoma. Neurooncol Pract, 6(6), 451–462. https://doi.org/10.1093/nop/npz019
Gittleman, Haley, Quinn T. Ostrom, L. C. Stetson, Kristin Waite, Tiffany R. Hodges, Christina H. Wright, James Wright, et al. “Sex is an important prognostic factor for glioblastoma but not for nonglioblastoma.Neurooncol Pract 6, no. 6 (December 2019): 451–62. https://doi.org/10.1093/nop/npz019.
Gittleman H, Ostrom QT, Stetson LC, Waite K, Hodges TR, Wright CH, et al. Sex is an important prognostic factor for glioblastoma but not for nonglioblastoma. Neurooncol Pract. 2019 Dec;6(6):451–62.
Gittleman, Haley, et al. “Sex is an important prognostic factor for glioblastoma but not for nonglioblastoma.Neurooncol Pract, vol. 6, no. 6, Dec. 2019, pp. 451–62. Pubmed, doi:10.1093/nop/npz019.
Gittleman H, Ostrom QT, Stetson LC, Waite K, Hodges TR, Wright CH, Wright J, Rubin JB, Berens ME, Lathia J, Connor JR, Kruchko C, Sloan AE, Barnholtz-Sloan JS. Sex is an important prognostic factor for glioblastoma but not for nonglioblastoma. Neurooncol Pract. 2019 Dec;6(6):451–462.
Journal cover image

Published In

Neurooncol Pract

DOI

ISSN

2054-2577

Publication Date

December 2019

Volume

6

Issue

6

Start / End Page

451 / 462

Location

England