Effects of Lifelong Musicianship on White Matter Integrity and Cognitive Brain Reserve.

Journal Article (Journal Article)

There is a significant body of research that has identified specific, high-end cognitive demand activities and lifestyles that may play a role in building cognitive brain reserve, including volume changes in gray matter and white matter, increased structural connectivity, and enhanced categorical perception. While normal aging produces trends of decreasing white matter (WM) integrity, research on cognitive brain reserve suggests that complex sensory-motor activities across the life span may slow down or reverse these trends. Previous research has focused on structural and functional changes to the human brain caused by training and experience in both linguistic (especially bilingualism) and musical domains. The current research uses diffusion tensor imaging to examine the integrity of subcortical white matter fiber tracts in lifelong musicians. Our analysis, using Tortoise and ICBM-81, reveals higher fractional anisotropy, an indicator of greater WM integrity, in aging musicians in bilateral superior longitudinal fasciculi and bilateral uncinate fasciculi. Statistical methods used include Fisher's method and linear regression analysis. Another unique aspect of this study is the accompanying behavioral performance data for each participant. This is one of the first studies to look specifically at musicianship across the life span and its impact on bilateral WM integrity in aging.

Full Text

Duke Authors

Cited Authors

  • Andrews, E; Eierud, C; Banks, D; Harshbarger, T; Michael, A; Rammell, C

Published Date

  • January 6, 2021

Published In

Volume / Issue

  • 11 / 1

PubMed ID

  • 33419228

Pubmed Central ID

  • PMC7825624

International Standard Serial Number (ISSN)

  • 2076-3425

Digital Object Identifier (DOI)

  • 10.3390/brainsci11010067

Language

  • eng

Conference Location

  • Switzerland