Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults.
Journal Article (Journal Article)
OBJECTIVE: To determine the relationship between affective measures and cognition before and after non-cardiac surgery in older adults. METHODS: Observational prospective cohort study in 103 surgical patients age ≥ 60 years old. All participants underwent cognitive testing, Center for Epidemiologic Studies-Depression, and State Anxiety Inventory screening before and 6 weeks after surgery. Cognitive test scores were combined by factor analysis into 4 cognitive domains, whose mean was defined as the continuous cognitive index (CCI). Postoperative global cognitive change was defined by CCI change from before to after surgery, with negative CCI change indicating worsened postoperative global cognition and vice versa. RESULTS: Lower global cognition before surgery was associated with greater baseline depression severity (Spearman's r = -0.30, p = 0.002) and baseline anxiety severity (Spearman's r = -0.25, p = 0.010), and these associations were similar following surgery (r = -0.36, p < 0.001; r = -0.26, p = 0.008, respectively). Neither baseline depression or anxiety severity, nor postoperative changes in depression or anxiety severity, were associated with pre- to postoperative global cognitive change. CONCLUSIONS: Greater depression and anxiety severity were each associated with poorer cognitive performance both before and after surgery in older adults. Yet, neither baseline depression or anxiety symptoms, nor postoperative change in these symptoms, were associated with postoperative cognitive change.
Full Text
Duke Authors
- Berger, Miles
- Browndyke, Jeffrey Nicholas
- Cohen, Harvey Jay
- Devinney, Michael
- Mathew, Joseph P.
- Moretti, Eugene William
- Moul, Judd Wendell
- Smith, Patrick J
- Whitson, Heather Elizabeth
Cited Authors
- Oyeyemi, DM; Cooter, M; Chung, S; Whitson, HE; Browndyke, JN; Devinney, MJ; Smith, PJ; Garrigues, GE; Moretti, E; Moul, JW; Cohen, HJ; Mathew, JP; Berger, M; MADCO-PC Study Team Investigators,
Published Date
- January 2022
Published In
Volume / Issue
- 35 / 1
Start / End Page
- 145 - 154
PubMed ID
- 33380241
Pubmed Central ID
- PMC8243391
International Standard Serial Number (ISSN)
- 0891-9887
Digital Object Identifier (DOI)
- 10.1177/0891988720978791
Language
- eng
Conference Location
- United States