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Radiological Society of North America/Quantitative Imaging Biomarker Alliance Shear Wave Speed Bias Quantification in Elastic and Viscoelastic Phantoms.

Publication ,  Journal Article
Palmeri, ML; Milkowski, A; Barr, R; Carson, P; Couade, M; Chen, J; Chen, S; Dhyani, M; Ehman, R; Garra, B; Gee, A; Guenette, G; Hah, Z ...
Published in: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
March 2021

To quantify the bias of shear wave speed (SWS) measurements between different commercial ultrasonic shear elasticity systems and a magnetic resonance elastography (MRE) system in elastic and viscoelastic phantoms.Two elastic phantoms, representing healthy through fibrotic liver, were measured with 5 different ultrasound platforms, and 3 viscoelastic phantoms, representing healthy through fibrotic liver tissue, were measured with 12 different ultrasound platforms. Measurements were performed with different systems at different sites, at 3 focal depths, and with different appraisers. The SWS bias across the systems was quantified as a function of the system, site, focal depth, and appraiser. A single MRE research system was also used to characterize these phantoms using discrete frequencies from 60 to 500 Hz.The SWS from different systems had mean difference 95% confidence intervals of ±0.145 m/s (±9.6%) across both elastic phantoms and ± 0.340 m/s (±15.3%) across the viscoelastic phantoms. The focal depth and appraiser were less significant sources of SWS variability than the system and site. Magnetic resonance elastography best matched the ultrasonic SWS in the viscoelastic phantoms using a 140 Hz source but had a - 0.27 ± 0.027-m/s (-12.2% ± 1.2%) bias when using the clinically implemented 60-Hz vibration source.Shear wave speed reconstruction across different manufacturer systems is more consistent in elastic than viscoelastic phantoms, with a mean difference bias of < ±10% in all cases. Magnetic resonance elastographic measurements in the elastic and viscoelastic phantoms best match the ultrasound systems with a 140-Hz excitation but have a significant negative bias operating at 60 Hz. This study establishes a foundation for meaningful comparison of SWS measurements made with different platforms.

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Published In

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

DOI

EISSN

1550-9613

ISSN

0278-4297

Publication Date

March 2021

Volume

40

Issue

3

Start / End Page

569 / 581

Related Subject Headings

  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • North America
  • Humans
  • Elasticity Imaging Techniques
  • Elasticity
  • Biomarkers
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Palmeri, M. L., Milkowski, A., Barr, R., Carson, P., Couade, M., Chen, J., … Hall, T. J. (2021). Radiological Society of North America/Quantitative Imaging Biomarker Alliance Shear Wave Speed Bias Quantification in Elastic and Viscoelastic Phantoms. Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine, 40(3), 569–581. https://doi.org/10.1002/jum.15609
Palmeri, Mark L., Andy Milkowski, Richard Barr, Paul Carson, Mathieu Couade, Jun Chen, Shigao Chen, et al. “Radiological Society of North America/Quantitative Imaging Biomarker Alliance Shear Wave Speed Bias Quantification in Elastic and Viscoelastic Phantoms.Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine 40, no. 3 (March 2021): 569–81. https://doi.org/10.1002/jum.15609.
Palmeri ML, Milkowski A, Barr R, Carson P, Couade M, Chen J, et al. Radiological Society of North America/Quantitative Imaging Biomarker Alliance Shear Wave Speed Bias Quantification in Elastic and Viscoelastic Phantoms. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 2021 Mar;40(3):569–81.
Palmeri, Mark L., et al. “Radiological Society of North America/Quantitative Imaging Biomarker Alliance Shear Wave Speed Bias Quantification in Elastic and Viscoelastic Phantoms.Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine, vol. 40, no. 3, Mar. 2021, pp. 569–81. Epmc, doi:10.1002/jum.15609.
Palmeri ML, Milkowski A, Barr R, Carson P, Couade M, Chen J, Chen S, Dhyani M, Ehman R, Garra B, Gee A, Guenette G, Hah Z, Lynch T, Macdonald M, Managuli R, Miette V, Nightingale KR, Obuchowski N, Rouze NC, Morris DC, Fielding S, Deng Y, Chan D, Choudhury K, Yang S, Samir AE, Shamdasani V, Urban M, Wear K, Xie H, Ozturk A, Qiang B, Song P, McAleavey S, Rosenzweig S, Wang M, Okamura Y, McLaughlin G, Chen Y, Napolitano D, Carlson L, Erpelding T, Hall TJ. Radiological Society of North America/Quantitative Imaging Biomarker Alliance Shear Wave Speed Bias Quantification in Elastic and Viscoelastic Phantoms. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 2021 Mar;40(3):569–581.

Published In

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

DOI

EISSN

1550-9613

ISSN

0278-4297

Publication Date

March 2021

Volume

40

Issue

3

Start / End Page

569 / 581

Related Subject Headings

  • Phantoms, Imaging
  • Nuclear Medicine & Medical Imaging
  • North America
  • Humans
  • Elasticity Imaging Techniques
  • Elasticity
  • Biomarkers
  • 3202 Clinical sciences
  • 1103 Clinical Sciences