Radiological Society of North America/Quantitative Imaging Biomarker Alliance Shear Wave Speed Bias Quantification in Elastic and Viscoelastic Phantoms.
Journal Article (Journal Article)
Objectives
To quantify the bias of shear wave speed (SWS) measurements between different commercial ultrasonic shear elasticity systems and a magnetic resonance elastography (MRE) system in elastic and viscoelastic phantoms.Methods
Two elastic phantoms, representing healthy through fibrotic liver, were measured with 5 different ultrasound platforms, and 3 viscoelastic phantoms, representing healthy through fibrotic liver tissue, were measured with 12 different ultrasound platforms. Measurements were performed with different systems at different sites, at 3 focal depths, and with different appraisers. The SWS bias across the systems was quantified as a function of the system, site, focal depth, and appraiser. A single MRE research system was also used to characterize these phantoms using discrete frequencies from 60 to 500 Hz.Results
The SWS from different systems had mean difference 95% confidence intervals of ±0.145 m/s (±9.6%) across both elastic phantoms and ± 0.340 m/s (±15.3%) across the viscoelastic phantoms. The focal depth and appraiser were less significant sources of SWS variability than the system and site. Magnetic resonance elastography best matched the ultrasonic SWS in the viscoelastic phantoms using a 140 Hz source but had a - 0.27 ± 0.027-m/s (-12.2% ± 1.2%) bias when using the clinically implemented 60-Hz vibration source.Conclusions
Shear wave speed reconstruction across different manufacturer systems is more consistent in elastic than viscoelastic phantoms, with a mean difference bias of < ±10% in all cases. Magnetic resonance elastographic measurements in the elastic and viscoelastic phantoms best match the ultrasound systems with a 140-Hz excitation but have a significant negative bias operating at 60 Hz. This study establishes a foundation for meaningful comparison of SWS measurements made with different platforms.Full Text
Duke Authors
Cited Authors
- Palmeri, ML; Milkowski, A; Barr, R; Carson, P; Couade, M; Chen, J; Chen, S; Dhyani, M; Ehman, R; Garra, B; Gee, A; Guenette, G; Hah, Z; Lynch, T; Macdonald, M; Managuli, R; Miette, V; Nightingale, KR; Obuchowski, N; Rouze, NC; Morris, DC; Fielding, S; Deng, Y; Chan, D; Choudhury, K; Yang, S; Samir, AE; Shamdasani, V; Urban, M; Wear, K; Xie, H; Ozturk, A; Qiang, B; Song, P; McAleavey, S; Rosenzweig, S; Wang, M; Okamura, Y; McLaughlin, G; Chen, Y; Napolitano, D; Carlson, L; Erpelding, T; Hall, TJ
Published Date
- March 2021
Published In
Volume / Issue
- 40 / 3
Start / End Page
- 569 - 581
PubMed ID
- 33410183
Pubmed Central ID
- PMC8082942
Electronic International Standard Serial Number (EISSN)
- 1550-9613
International Standard Serial Number (ISSN)
- 0278-4297
Digital Object Identifier (DOI)
- 10.1002/jum.15609
Language
- eng