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Endogenous Candida endophthalmitis: Who is really at risk?

Publication ,  Journal Article
Seidelman, J; Fleece, M; Bloom, A; Lydon, E; Yang, W; Arnold, C; Weber, DJ; Okeke, NL
Published in: J Infect
February 2021

OBJECTIVES: The Infectious Disease Society of America recommends that all patients with candidemia undergo a dilated retinal exam to exclude endogenous Candida endophthalmitis. Our objective was to determine if there are significant risk factors in candidemic patients for developing endogenous Candida endophthalmitis METHODS: We conducted a retrospective study of all candidemic patients at three academic medical centers between 2012 and 2017. We extracted risk factors for Candida endophthalmitis based on prior literature and compared them between patients with and without endophthalmitis. We then built a multivariate logistic regression model to assess which ones were significant. RESULTS: We found 771 patients with candidemia. 120 (15.6%) of these patients were diagnosed with Candida endophthalmitis. In our logistic regression analysis, central venous catheter presence (OR 8.35), intravenous drug use (OR 4.76), immunosuppression (OR 2.40), total parenteral nutrition recipient (OR 2.28), race (OR 1.65), age (OR 1.02), and gender (OR 0.57) were risk factors for developing Candida endophthalmitis. Additionally, Candida albicans was more likely to result in Candida endophthalmitis (OR 1.86). CONCLUSIONS: This cohort represents the largest study of risk factors for candidemic patients who developed endogenous Candida endophthalmitis. Based on our findings, clinicians should develop targeted and cost-effective strategies for endophthalmitis screening.

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Published In

J Infect

DOI

EISSN

1532-2742

Publication Date

February 2021

Volume

82

Issue

2

Start / End Page

276 / 281

Location

England

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Microbiology
  • Humans
  • Eye Infections, Fungal
  • Endophthalmitis
  • Candidiasis
  • Candida
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Chicago
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MLA
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Seidelman, J., Fleece, M., Bloom, A., Lydon, E., Yang, W., Arnold, C., … Okeke, N. L. (2021). Endogenous Candida endophthalmitis: Who is really at risk? J Infect, 82(2), 276–281. https://doi.org/10.1016/j.jinf.2020.12.032
Seidelman, Jessica, Molly Fleece, Allison Bloom, Emily Lydon, Wesley Yang, Christopher Arnold, David J. Weber, and Nwora Lance Okeke. “Endogenous Candida endophthalmitis: Who is really at risk?J Infect 82, no. 2 (February 2021): 276–81. https://doi.org/10.1016/j.jinf.2020.12.032.
Seidelman J, Fleece M, Bloom A, Lydon E, Yang W, Arnold C, et al. Endogenous Candida endophthalmitis: Who is really at risk? J Infect. 2021 Feb;82(2):276–81.
Seidelman, Jessica, et al. “Endogenous Candida endophthalmitis: Who is really at risk?J Infect, vol. 82, no. 2, Feb. 2021, pp. 276–81. Pubmed, doi:10.1016/j.jinf.2020.12.032.
Seidelman J, Fleece M, Bloom A, Lydon E, Yang W, Arnold C, Weber DJ, Okeke NL. Endogenous Candida endophthalmitis: Who is really at risk? J Infect. 2021 Feb;82(2):276–281.
Journal cover image

Published In

J Infect

DOI

EISSN

1532-2742

Publication Date

February 2021

Volume

82

Issue

2

Start / End Page

276 / 281

Location

England

Related Subject Headings

  • Risk Factors
  • Retrospective Studies
  • Microbiology
  • Humans
  • Eye Infections, Fungal
  • Endophthalmitis
  • Candidiasis
  • Candida
  • 3202 Clinical sciences
  • 1103 Clinical Sciences