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Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2.5) on all-cause mortality: a longitudinal cohort study in China.

Publication ,  Journal Article
Yao, Y; Liu, L; Guo, G; Zeng, Y; Ji, JS
Published in: Environ Health
March 14, 2021

BACKGROUND: The SIRT1 gene was associated with the lifespan in several organisms through inflammatory and oxidative stress pathways. Long-term air particulate matter (PM) is detrimental to health through the same pathways. METHODS: We used the Chinese Longitudinal Healthy Longevity Survey (CLHLS) to investigate whether there is a gene-environment (G × E) interaction of SIRT1 and air pollution on mortality in an older cohort in China. Among 7083 participants with a mean age of 81.1 years, we genotyped nine SIRT1 alleles for each participant and assessed PM2.5 concentration using 3-year average concentrations around each participant's residence. We used Cox-proportional hazards models to estimate the independent and joint effects of SIRT1 polymorphisms and PM2.5 exposure on all-cause mortality, adjusting for a set of confounders. RESULTS: There were 2843 deaths over 42,852 person-years. The mortality hazard ratio (HR) and 95% confidence interval (CI) for each 10 μg/m3 increase in PM2·5 was 1.08 (1.05-1.11); for SIRT1_391 was 0.77 (0.61, 0.98) in the recessive model after adjustment. In stratified analyses, participants carrying two SIRT1_391 minor alleles had a significantly higher HR for each 10 μg/m3 increase in PM2.5 than those carrying zero minor alleles (1.323 (95% CI: 1.088, 1.610) vs. 1.062 (1.028, 1.096) p for interaction = 0.03). Moreover, the interaction of SIRT1 and air pollution on mortality is significant among women but not among men. We did not see significant relationships for SIRT1_366, SIRT1_773, and SIRT1_720. CONCLUSION: We found a gene-environment interaction of SIRT1 and air pollution on mortality, future experimental studies are warranted to depict the mechanism observed in this study.

Duke Scholars

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Published In

Environ Health

DOI

EISSN

1476-069X

Publication Date

March 14, 2021

Volume

20

Issue

1

Start / End Page

25

Location

England

Related Subject Headings

  • Toxicology
  • Sirtuin 1
  • Polymorphism, Single Nucleotide
  • Particulate Matter
  • Mortality
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans
  • Genotype
 

Citation

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Yao, Y., Liu, L., Guo, G., Zeng, Y., & Ji, J. S. (2021). Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2.5) on all-cause mortality: a longitudinal cohort study in China. Environ Health, 20(1), 25. https://doi.org/10.1186/s12940-021-00718-x
Yao, Yao, Linxin Liu, Guang Guo, Yi Zeng, and John S. Ji. “Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2.5) on all-cause mortality: a longitudinal cohort study in China.Environ Health 20, no. 1 (March 14, 2021): 25. https://doi.org/10.1186/s12940-021-00718-x.
Yao, Yao, et al. “Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2.5) on all-cause mortality: a longitudinal cohort study in China.Environ Health, vol. 20, no. 1, Mar. 2021, p. 25. Pubmed, doi:10.1186/s12940-021-00718-x.
Journal cover image

Published In

Environ Health

DOI

EISSN

1476-069X

Publication Date

March 14, 2021

Volume

20

Issue

1

Start / End Page

25

Location

England

Related Subject Headings

  • Toxicology
  • Sirtuin 1
  • Polymorphism, Single Nucleotide
  • Particulate Matter
  • Mortality
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans
  • Genotype