Recent advances in the research and management of sepsis-associated DIC.

Journal Article (Journal Article;Review)

Disseminated intravascular coagulation (DIC) is a common and life-threatening complication in sepsis. Sepsis-associated DIC is recognized as the systemic activation in coagulation with suppressed fibrinolysis that leads to organ dysfunction in combination with systemic intravascular inflammation. In this process, thrombin contributes a key role in connecting both coagulation and inflammation. Endothelial injury, a result of sepsis, causes DIC due to the effect of multiple activated factors that include neutrophils, platelets, and damage-associated molecular patterns. Recent advances in the understanding of pathophysiology have made it possible to diagnose sepsis-associated DIC at earlier timing with better accuracy. However, progress in the treatment is still limited, and new therapeutics for sepsis-associated DIC are needed.

Full Text

Duke Authors

Cited Authors

  • Iba, T; Connors, JM; Nagaoka, I; Levy, JH

Published Date

  • January 2021

Published In

Volume / Issue

  • 113 / 1

Start / End Page

  • 24 - 33

PubMed ID

  • 33386597

Pubmed Central ID

  • PMC7775827

Electronic International Standard Serial Number (EISSN)

  • 1865-3774

Digital Object Identifier (DOI)

  • 10.1007/s12185-020-03053-y


  • eng

Conference Location

  • Japan