The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models.
Journal Article (Journal Article;Review)
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent age-related neurodegenerative diseases, and currently no effective clinical treatments exist for either, despite decades of clinical trials. The failure to translate preclinical findings into effective treatments is indicative of a problem in the current evaluation pipeline for potential therapeutics. At present, there are no useful animal models for AD and PD research that reflect the entire biology of the diseases, specifically, the more common non-Mendelian forms. Whereas the field continues to seek suitable rodent models for investigating potential therapeutics for these diseases, rodent models have still been used primarily for preclinical studies. Here, we advocate for a paradigm shift toward the application of human-induced pluripotent stem cell (hiPSC)-derived systems for PD and AD modeling and the development of improved human-based models in a dish for drug discovery and preclinical assessment of therapeutic targets.
Full Text
Duke Authors
Cited Authors
- MacDougall, G; Brown, LY; Kantor, B; Chiba-Falek, O
Published Date
- March 3, 2021
Published In
Volume / Issue
- 29 / 3
Start / End Page
- 949 - 972
PubMed ID
- 33429080
Pubmed Central ID
- PMC7934639
Electronic International Standard Serial Number (EISSN)
- 1525-0024
Digital Object Identifier (DOI)
- 10.1016/j.ymthe.2021.01.001
Language
- eng
Conference Location
- United States