Skip to main content
Journal cover image

Pregnancy Outcomes in Patients With Interstitial Lung Disease.

Publication ,  Conference
Clowse, MEB; Rajendran, A; Eudy, A; Giattino, S; Swaminathan, A; James, AH
Published in: Arthritis Care Res (Hoboken)
May 2023

OBJECTIVE: Women with interstitial lung disease (ILD) are recommended to avoid pregnancy based on limited data. This study seeks to determine maternal and pregnancy outcomes in the largest-to-date cohort of patients with ILD. METHODS: Medical records in the Duke University Health System were reviewed for pregnancies in patients with a diagnosis of ILD with underlying autoimmune disease. Pregnancies were classified as having very severe, severe, mild-moderate, or normal lung function based on pulmonary function tests (PFTs). Adverse pregnancy outcomes (APOs) were defined using the Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus and Antiphospholipid Syndrome APO (PROMISSE-APO) and Severe PROMISSE-APO criteria. RESULTS: Among 86 pregnancies in 60 women, 85% women were Black, 71% had sarcoidosis, and 29% had connective tissue disease (CTD)-associated ILD (CTD-ILD). Of the pregnancies with available PFTs (n = 59), 12% had very severe ILD, 25% had severe ILD, 51% had mild-moderate ILD, and 12% had normal lung function. PROMISSE-APOs occurred in 32% of pregnancies, including all pregnancies with very severe ILD (P = 0.02 across severity groups), 56% of pregnancies with CTD-ILD, and 23% with sarcoidosis (P = 0.02). Severe PROMISSE-APOs occurred in 15% of pregnancies, including 60% with very severe ILD and 28% with CTD-ILD. There were no maternal deaths. One woman required an intensive care hospital stay during pregnancy. Three women had volume overload after delivery that resolved with medical management. Seven women received oxygen during delivery, although none were intubated. CONCLUSION: Although APOs were common in women with very severe ILD and underlying CTD, overall maternal morbidity and mortality were low. These data suggest women with ILD may be able to safely attempt pregnancy.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

May 2023

Volume

75

Issue

5

Start / End Page

1166 / 1174

Location

United States

Related Subject Headings

  • Sarcoidosis
  • Pregnancy Outcome
  • Pregnancy
  • Male
  • Lupus Erythematosus, Systemic
  • Lung Diseases, Interstitial
  • Humans
  • Female
  • Connective Tissue Diseases
  • 4201 Allied health and rehabilitation science
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Clowse, M. E. B., Rajendran, A., Eudy, A., Giattino, S., Swaminathan, A., & James, A. H. (2023). Pregnancy Outcomes in Patients With Interstitial Lung Disease. In Arthritis Care Res (Hoboken) (Vol. 75, pp. 1166–1174). United States. https://doi.org/10.1002/acr.24814
Clowse, Megan E. B., Aardra Rajendran, Amanda Eudy, Stephanie Giattino, Aparna Swaminathan, and Andra H. James. “Pregnancy Outcomes in Patients With Interstitial Lung Disease.” In Arthritis Care Res (Hoboken), 75:1166–74, 2023. https://doi.org/10.1002/acr.24814.
Clowse MEB, Rajendran A, Eudy A, Giattino S, Swaminathan A, James AH. Pregnancy Outcomes in Patients With Interstitial Lung Disease. In: Arthritis Care Res (Hoboken). 2023. p. 1166–74.
Clowse, Megan E. B., et al. “Pregnancy Outcomes in Patients With Interstitial Lung Disease.Arthritis Care Res (Hoboken), vol. 75, no. 5, 2023, pp. 1166–74. Pubmed, doi:10.1002/acr.24814.
Clowse MEB, Rajendran A, Eudy A, Giattino S, Swaminathan A, James AH. Pregnancy Outcomes in Patients With Interstitial Lung Disease. Arthritis Care Res (Hoboken). 2023. p. 1166–1174.
Journal cover image

Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

May 2023

Volume

75

Issue

5

Start / End Page

1166 / 1174

Location

United States

Related Subject Headings

  • Sarcoidosis
  • Pregnancy Outcome
  • Pregnancy
  • Male
  • Lupus Erythematosus, Systemic
  • Lung Diseases, Interstitial
  • Humans
  • Female
  • Connective Tissue Diseases
  • 4201 Allied health and rehabilitation science