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Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis.

Publication ,  Journal Article
Dinh, P-UC; Paudel, D; Brochu, H; Popowski, KD; Gracieux, MC; Cores, J; Huang, K; Hensley, MT; Harrell, E; Vandergriff, AC; George, AK; Hu, S ...
Published in: Nat Commun
February 28, 2020

Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which persistent injury results in scar tissue formation. As fibrosis thickens, the lung tissue loses the ability to facilitate gas exchange and provide cells with needed oxygen. Currently, IPF has few treatment options and no effective therapies, aside from lung transplant. Here we present a series of studies utilizing lung spheroid cell-secretome (LSC-Sec) and exosomes (LSC-Exo) by inhalation to treat different models of lung injury and fibrosis. Analysis reveals that LSC-Sec and LSC-Exo treatments could attenuate and resolve bleomycin- and silica-induced fibrosis by reestablishing normal alveolar structure and decreasing both collagen accumulation and myofibroblast proliferation. Additionally, LSC-Sec and LSC-Exo exhibit superior therapeutic benefits than their counterparts derived from mesenchymal stem cells in some measures. We showed that an inhalation treatment of secretome and exosome exhibited therapeutic potential for lung regeneration in two experimental models of pulmonary fibrosis.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

February 28, 2020

Volume

11

Issue

1

Start / End Page

1064

Location

England

Related Subject Headings

  • Spheroids, Cellular
  • Silicon Dioxide
  • Proteomics
  • Myofibroblasts
  • Mice
  • Mesenchymal Stem Cells
  • Lung Injury
  • Lung
  • Idiopathic Pulmonary Fibrosis
  • Humans
 

Citation

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Dinh, P.-U., Paudel, D., Brochu, H., Popowski, K. D., Gracieux, M. C., Cores, J., … Cheng, K. (2020). Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis. Nat Commun, 11(1), 1064. https://doi.org/10.1038/s41467-020-14344-7
Dinh, Phuong-Uyen C., Dipti Paudel, Hayden Brochu, Kristen D. Popowski, M Cyndell Gracieux, Jhon Cores, Ke Huang, et al. “Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis.Nat Commun 11, no. 1 (February 28, 2020): 1064. https://doi.org/10.1038/s41467-020-14344-7.
Dinh P-UC, Paudel D, Brochu H, Popowski KD, Gracieux MC, Cores J, et al. Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis. Nat Commun. 2020 Feb 28;11(1):1064.
Dinh, Phuong-Uyen C., et al. “Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis.Nat Commun, vol. 11, no. 1, Feb. 2020, p. 1064. Pubmed, doi:10.1038/s41467-020-14344-7.
Dinh P-UC, Paudel D, Brochu H, Popowski KD, Gracieux MC, Cores J, Huang K, Hensley MT, Harrell E, Vandergriff AC, George AK, Barrio RT, Hu S, Allen TA, Blackburn K, Caranasos TG, Peng X, Schnabel LV, Adler KB, Lobo LJ, Goshe MB, Cheng K. Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis. Nat Commun. 2020 Feb 28;11(1):1064.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

February 28, 2020

Volume

11

Issue

1

Start / End Page

1064

Location

England

Related Subject Headings

  • Spheroids, Cellular
  • Silicon Dioxide
  • Proteomics
  • Myofibroblasts
  • Mice
  • Mesenchymal Stem Cells
  • Lung Injury
  • Lung
  • Idiopathic Pulmonary Fibrosis
  • Humans