Quantitative methods and bayesian models for flow cytometry analysis in HIV/AIDS research

Book Section

Flow cytometry is a multiparameter single-cell assay ubiquitous in HIV/AIDS clinical and research settings for evaluating the immune response to the virus, therapy, and vaccination. In clinical practice, flow cytometry is used to monitor the CD4 and CD8 T cell counts of HIV-infected subjects. In research settings, flow cytometry is used to evaluate innate and antigen-specific responses to the HIV virus, so as to better understand pathogenesis, the mechanisms responsible for long-term nonprogression, and to develop effective immune-based interventions. In vaccine development, there is significant interest in the potential of flow-based biomarkers that can serve as surrogate measures of efficacy.

Full Text

Duke Authors

Cited Authors

  • Lin, L; Chan, C

Published Date

  • January 1, 2017

Book Title

  • Quantitative Methods for HIV/AIDS Research

Start / End Page

  • 135 - 156

International Standard Book Number 13 (ISBN-13)

  • 9781498734233

Digital Object Identifier (DOI)

  • 10.1201/9781315120805

Citation Source

  • Scopus