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As Infliximab Use for Ulcerative Colitis Has Increased, so Has the Rate of Surgical Resection.

Publication ,  Journal Article
Kin, C; Kate Bundorf, M
Published in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
July 2017

Infliximab was approved for ulcerative colitis in 2005 after randomized trials showed it reduced the risk of colectomy. Its effect on population-level surgery rates is unknown. Our aim is to assess the impact of infliximab approval for ulcerative colitis on surgical intervention.Retrospective review of a private insurance claims database (2002 to 2013) was performed of patients aged 18-64 diagnosed with ulcerative colitis and with 2 years of follow-up. Outcome measures were infliximab treatment and surgical resection. Multivariable logistic regression used independent variables of time period of diagnosis, age, gender, comorbidities, and insurance type.The cohort included 58,681 patients. Age, gender, and comorbidities were comparable across time periods. Patients diagnosed in the post-infliximab period had greater odds of undergoing infliximab treatment within the first year of diagnosis than those in the pre-infliximab era (OR = 2.88, p < 0.001). However, the odds of undergoing total colectomy or total proctocolectomy were also higher in patients diagnosed in the post-infliximab period (OR 1.5, p < 0.001).The use of infliximab for ulcerative colitis has, as expected, increased since its approval, but so has the risk of surgery. Thus, the introduction of biologic therapy has not decreased the risk for surgery for this patient population.

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Published In

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

DOI

EISSN

1873-4626

ISSN

1091-255X

Publication Date

July 2017

Volume

21

Issue

7

Start / End Page

1159 / 1165

Related Subject Headings

  • Young Adult
  • Surgery
  • Retrospective Studies
  • Outcome Assessment, Health Care
  • Middle Aged
  • Male
  • Infliximab
  • Humans
  • Gastrointestinal Agents
  • Female
 

Citation

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ICMJE
MLA
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Kin, C., & Kate Bundorf, M. (2017). As Infliximab Use for Ulcerative Colitis Has Increased, so Has the Rate of Surgical Resection. Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract, 21(7), 1159–1165. https://doi.org/10.1007/s11605-017-3431-0
Kin, Cindy, and M. Kate Bundorf. “As Infliximab Use for Ulcerative Colitis Has Increased, so Has the Rate of Surgical Resection.Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract 21, no. 7 (July 2017): 1159–65. https://doi.org/10.1007/s11605-017-3431-0.
Kin C, Kate Bundorf M. As Infliximab Use for Ulcerative Colitis Has Increased, so Has the Rate of Surgical Resection. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2017 Jul;21(7):1159–65.
Kin, Cindy, and M. Kate Bundorf. “As Infliximab Use for Ulcerative Colitis Has Increased, so Has the Rate of Surgical Resection.Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract, vol. 21, no. 7, July 2017, pp. 1159–65. Epmc, doi:10.1007/s11605-017-3431-0.
Kin C, Kate Bundorf M. As Infliximab Use for Ulcerative Colitis Has Increased, so Has the Rate of Surgical Resection. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2017 Jul;21(7):1159–1165.
Journal cover image

Published In

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

DOI

EISSN

1873-4626

ISSN

1091-255X

Publication Date

July 2017

Volume

21

Issue

7

Start / End Page

1159 / 1165

Related Subject Headings

  • Young Adult
  • Surgery
  • Retrospective Studies
  • Outcome Assessment, Health Care
  • Middle Aged
  • Male
  • Infliximab
  • Humans
  • Gastrointestinal Agents
  • Female