ALSUntangled 59: Tamoxifen.
Here we use the ALSUntangled methodology to review Tamoxifen as an ALS treatment. We show that it has plausible mechanisms, a positive preclinical study, a case report and 2 small trials suggesting benefits. We show that it appears reasonably safe, though there is a small risk of developing cancer with long term use. While we cannot yet endorse this as an ALS treatment, there is enough evidence to warrant another larger ALS trial.
Bedlack, R; Kihuwa-Mani, S; Barkhaus, PE; Bereman, M; Caress, JB; Crayle, J; Pattee, GL; Heiman Patterson, T; Wicks, P; Zach, N; Carter, GT; Salmon, K
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