ALSUntangled 59: Tamoxifen.

Journal Article (Journal Article)

Here we use the ALSUntangled methodology to review Tamoxifen as an ALS treatment. We show that it has plausible mechanisms, a positive preclinical study, a case report and 2 small trials suggesting benefits. We show that it appears reasonably safe, though there is a small risk of developing cancer with long term use. While we cannot yet endorse this as an ALS treatment, there is enough evidence to warrant another larger ALS trial.

Full Text

Duke Authors

Cited Authors

  • Bedlack, R; Kihuwa-Mani, S; Barkhaus, PE; Bereman, M; Caress, JB; Crayle, J; Pattee, GL; Heiman Patterson, T; Wicks, P; Zach, N; Carter, GT; Salmon, K

Published Date

  • November 2021

Published In

Volume / Issue

  • 22 / 7-8

Start / End Page

  • 595 - 598

PubMed ID

  • 33474997

Electronic International Standard Serial Number (EISSN)

  • 2167-9223

Digital Object Identifier (DOI)

  • 10.1080/21678421.2021.1876731


  • eng

Conference Location

  • England